Hematopoietic Stem/Progenitor Cells and the Pathogenesis of HIV/AIDS

Abstract

The interaction between human immunodeficiency virus (HIV) and hematopoietic stem/progenitor cells (HSPCs) has been of great interest. However, it remains unclear whether HSPCs can act as viral reservoirs. Many studies have reported the presence of latently infected HSPCs in the bone marrow of HIV-infected patients, whereas many other investigators have reported negative results. Hence, further evidence is required to elucidate this controversy. The other arm of HSPC investigations of HIV infection involves dynamics analysis in the early and late stages of infection to understand the impact on the pathogenesis of acquired immunodeficiency syndrome. Several recent studies have suggested reduced amounts and/or functional impairment of multipotent, myeloid, and lymphoid progenitors in HIV infection that may contribute to hematological manifestations, including anemia, pancytopenia, and T-cell depletion. In addition, ongoing and future studies on the senescence of HSPCs are expected to further the understanding of HIV pathogenesis. This mini review summarizes reports describing the basic aspects of hematopoiesis in response to HIV infection and offers insights into the association of HIV infection/exposure of the host HSPCs and hematopoietic potential.

Keywords: acquired immunodeficiency syndrome; hematopoiesis; hematopoietic stem/progenitor cells; human immunodeficiency virus; senescence.

Figure 1

A summary of recent topics regarding HIV-1 pathogenesis associated with subsets of hematopoietic stem/progenitor cells. CFU-GM, granulocyte-macrophage colony-forming unit; GMP, granulocyte-macrophage progenitor; HSPC, hematopoietic stem progenitor cell; LP, lymphoid progenitor; MEP, megakaryocyte–erythrocyte progenitor; pDC, plasmacytoid dendritic cell.