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Comment
. 2020 Apr 1;143(4):e25.
doi: 10.1093/brain/awaa043.

The repeat variant in MSH3 is not a genetic modifier for spinocerebellar ataxia type 3 and Friedreich's ataxia

Wai Yan Yau  1 , Mafalda Raposo  2   3 , Conceição Bettencourt  4   5 , Robyn Labrum  6 , João Vasconcelos  7 , Michael H Parkinson  8 , Paola Giunti  8 , Nicholas W Wood  1   6 , Manuela Lima  2   3 , Henry Houlden  1   6
Affiliations
Comment

The repeat variant in MSH3 is not a genetic modifier for spinocerebellar ataxia type 3 and Friedreich's ataxia

Wai Yan Yau et al. Brain. .
No abstract available

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Figures

Figure 1
Figure 1
The number of MSH3 3a repeat alleles is not associated with SCA3 and FRDA AAO. Box plots for AAO adjusted for the inherited CAG length in SCA3 (A) and adjusted for the inherited GAA lengths in FRDA (B). The adjusted AAO is subtracted from the mean AAOs of SCA3 and FRDA cohorts, respectively. The box indicates the 95% confidence intervals of the mean, the horizontal line within the box the mean and the whiskers the standard deviations.
Figure 2
Figure 2
The number of MSH3 3a repeat alleles is not associated with annual change in SARA. Box plots for annual change in SARA adjusted for the disease duration and baseline SARA. The box indicates the 95% confidence intervals of the mean, the horizontal line within the box the mean and the whiskers the standard deviations.
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References

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