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Comment
. 2020 Mar 9;52(5):546-547.
doi: 10.1016/j.devcel.2020.02.009.

VEGF Drives the Car toward Better Gas Exchange

Jaymin J Kathiriya  1 , Harold A Chapman  2
Affiliations
Comment

VEGF Drives the Car toward Better Gas Exchange

Jaymin J Kathiriya et al. Dev Cell. .

Abstract

How lung epithelium and endothelium co-develop to maintain structural integrity of alveoli remains unclear. In this issue of Developmental Cell, Ellis et al. define how epithelial Vegfa directs development of a distinct endothelial cell population that ultimately plays a critical role in ensuring appropriate alveolar septation during alveologenesis.

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Figures

Figure 1.
Figure 1.. Epithelial VEGFA Specifies Car4+ Endothelial Cells That Drive Alveolar Septation
Car4+ endothelial cells (ECs) are separated from VEGFA-secreting AT1 cells by a thin basement membrane devoid of pericytes, while Car4− ECs line the thicker basement membrane. The Car4+ ECs, along with myofibroblasts, contribute to alveolar septation during alveologenesis (blue arrows). These vessels, unlike other vessels comprised of Car4− ECs, are lost with disruption of epithelial VEGFA, ultimately causing incomplete alveolar septation culminating in emphysematous alveoli.
See this image and copyright information in PMC

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References

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