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. 2021 Oct 13;224(7):1147-1151.
doi: 10.1093/infdis/jiaa101.

Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh

Frank B Williams  1 , Abdul Kader  2 , E Ross Colgate  1 , Dorothy M Dickson  1 , Marya Carmolli  1 , Muhammad Ikhtear Uddin  2 , Salma Sharmin  2 , Shahidul Islam  2 , Taufiqur Rahman Bhuiyan  2 , Masud Alam  2 , Uma Nayak  3 , Josyf C Mychaleckyj  3 , William A Petri  4 , Rashidul Haque  2 , Firdausi Qadri  2 , Beth D Kirkpatrick  1 , Benjamin Lee  1
Affiliations

Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh

Frank B Williams et al. J Infect Dis. .

Abstract

Secretor status controls mucosal histo-blood group antigen expression and is associated with susceptibility to rotavirus (RV) diarrhea, with nonsecretors less susceptible to symptomatic infection. The role of breast milk secretor status on oral live-attenuated RV vaccine response in breastfed infants has not been explored. In a monovalent G1P[8] RV vaccine (Rotarix) trial in Bangladesh, RV-specific plasma immunoglobulin A antibody seroconversion rates were higher among infants of maternal nonsecretors (39%) than infants of maternal secretors (23%; P = .001). Maternal status remained a significant predictor when correcting for infant status (P = .002). Maternal secretor status should be considered when interpreting oral RV vaccine responses in low- and middle-income settings. Clinical Trials Registration. NCT01375647.

Keywords: Breast Milk; Oral vaccine; Rotavirus; Secretor.

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