Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Apr;147(2):297-307.
doi: 10.1007/s11060-020-03451-6. Epub 2020 Mar 9.

Trends in glioblastoma: outcomes over time and type of intervention: a systematic evidence based analysis

Lina Marenco-Hillembrand  1 , Olindi Wijesekera  2 , Paola Suarez-Meade  1 , David Mampre  3 , Christina Jackson  4 , Jennifer Peterson  5 , Daniel Trifiletti  5 , Julie Hammack  6 , Kyle Ortiz  7 , Elizabeth Lesser  8 , Matthew Spiegel  8 , Calder Prevatt  1 , Maria Hawayek  7 , Alfredo Quinones-Hinojosa  1 , Kaisorn L Chaichana  9
Affiliations

Trends in glioblastoma: outcomes over time and type of intervention: a systematic evidence based analysis

Lina Marenco-Hillembrand et al. J Neurooncol. 2020 Apr.

Abstract

Introduction: Despite aggressive treatment with chemoradiotherapy and maximum surgical resection, survival in patients with glioblastoma (GBM) remains poor. Ongoing efforts are aiming to prolong the lifespan of these patients; however, disparities exist in reported survival values with lack of clear evidence that objectively examines GBM survival trends. We aim to describe the current status and advances in the survival of patients with GBM, by analyzing median overall survival through time and between treatment modalities.

Methods: A systematic review was conducted according to PRISMA guidelines to identify articles of newly diagnosed glioblastoma from 1978 to 2018. Full-text glioblastoma papers with human subjects, ≥ 18 years old, and n ≥ 25, were included for evaluation.

Results: The central tendency of median overall survival (MOS) was 13.5 months (2.3-29.6) and cumulative 5-year survival was 5.8% (0.01%-29.1%), with a significant difference in survival between studies that predate versus postdate the implementation of temozolomide and radiation, [12.5 (2.3-28) vs 15.6 (3.8-29.6) months, P < 0.001]. In clinical trials, bevacizumab [18.2 (10.6-23.0) months], tumor treating fields (TTF) [20.7 (20.5-20.9) months], and vaccines [19.2 (15.3-26.0) months] reported the highest central measure of median survival.

Conclusion: Coadministration with radiotherapy and temozolomide provided a statistically significant increase in survival for patients suffering from glioblastoma. However, the natural history for GBM remains poor. Therapies including TTF pooled values of MOS and provide means of prolonging the survival of GBM patients.

Keywords: Analysis; Epidemiology; Geographic location; Glioblastoma; Glioma; Neoplasms; Therapy; Treatment; Trends; survival.

PubMed Disclaimer

References

    1. Ostrom QT, Gittleman H, Liao P, Vecchione-Koval T, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS (2017) CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010–2014. Neuro Oncol 19:v1–v88. https://doi.org/10.1093/neuonc/nox158 - DOI - PubMed - PMC
    1. Perry JR, Laperriere N, O'Callaghan CJ, Brandes AA, Menten J, Phillips C, Fay M, Nishikawa R, Cairncross JG, Roa W, Osoba D, Rossiter JP, Sahgal A, Hirte H, Laigle-Donadey F, Franceschi E, Chinot O, Golfinopoulos V, Fariselli L, Wick A, Feuvret L, Back M, Tills M, Winch C, Baumert BG, Wick W, Ding K, Mason WP (2017) Short-course radiation plus temozolomide in elderly patients with glioblastoma. N Engl J Med 376:1027–1037. https://doi.org/10.1056/NEJMoa1611977 - DOI - PubMed
    1. Raysi Dehcordi S, De Paulis D, Marzi S, Ricci A, Cimini A, Cifone MG, Galzio RJ (2012) Survival prognostic factors in patients with glioblastoma: our experience. J Neurosurg Sci 56:239–245 - PubMed
    1. Roberts PS, Nuno M, Sherman D, Asher A, Wertheimer J, Riggs RV, Patil CG (2014) The impact of inpatient rehabilitation on function and survival of newly diagnosed patients with glioblastoma. Pm r 6:514–521. https://doi.org/10.1016/j.pmrj.2013.12.007 - DOI - PubMed
    1. Chaichana KL, Chaichana KK, Olivi A, Weingart JD, Bennett R, Brem H, Quinones-Hinojosa A (2011) Surgical outcomes for older patients with glioblastoma multiforme: preoperative factors associated with decreased survival. J Neurosurg 114:587–594. https://doi.org/10.3171/2010.8.Jns1081 - DOI - PubMed

Publication types

LinkOut - more resources