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Meta-Analysis
. 2020 Sep;14(5):587-595.
doi: 10.1111/irv.12736. Epub 2020 Mar 10.

Seroprevalence of H7N9 infection among humans: A systematic review and meta-analysis

Qiang Wang  1   2 , Ke Xu  3 , Weihua Xie  1   2 , Liuqing Yang  1   2 , Haiyan Chen  4 , Naiyang Shi  1   2 , Changjun Bao  3 , Haodi Huang  3 , Xuefeng Zhang  3 , Yilan Liao  5 , Hui Jin  1   2
Affiliations
Meta-Analysis

Seroprevalence of H7N9 infection among humans: A systematic review and meta-analysis

Qiang Wang et al. Influenza Other Respir Viruses. 2020 Sep.

Abstract

In spring 2013, a novel avian-origin influenza A (H7N9) virus emerged in mainland China. The burden of H7N9 infection was estimated based on systematic review and meta-analysis. The systematic search for available literature was conducted using Chinese and English databases. We calculated the pooled seroprevalence of H7N9 infection and its 95% confidence interval by using Freeman-Tukey double arcsine transformation. Out of 16 890 records found using Chinese and English databases, 54 articles were included in the meta-analysis. These included studies of a total of 64 107 individuals. The pooled seroprevalence of H7N9 infection among humans was 0.122% (95% CI: 0.023, 0.275). In high-risk populations, the highest pooled seroprevalence was observed among close contacts (1.075%, 95% CI: 0.000, 4.357). The seroprevalence among general population was (0.077%, 95% CI: 0.011, 0.180). Our study discovered that asymptomatic infection of H7N9 virus did occur, even if the seroprevalence among humans was low.

Keywords: H7N9; influenza A; meta-analysis; seroprevalence; systematic review.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Flowchart of the literature search and study selection
Figure 2
Figure 2
Seroprevalence of H7N9 virus among humans
See this image and copyright information in PMC

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