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. 2020 Feb 27:7:2374289520906526.
doi: 10.1177/2374289520906526. eCollection 2020 Jan-Dec.

Educational Case: Systemic Mastocytosis with an Associated Hematological Neoplasm

Brenda Mai  1 , Md A Wahed  1 , Lei Chen  1 , Nghia D Nguyen  1 , Xiaohong Iris Wang  1 , Zhihong Hu  1
Affiliations

Educational Case: Systemic Mastocytosis with an Associated Hematological Neoplasm

Brenda Mai et al. Acad Pathol. .

Abstract

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.1.

Keywords: acute myeloid leukemia; chronic myeloid leukemia; hematopathology; myelodysplastic syndromes; myeloid neoplasia; myeloproliferative neoplasms; organ system pathology; pathology competencies.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
This peripheral blood smear reveals the presence of large blasts with fine chromatin and prominent nucleoli. One nucleated red blood cell is present (arrow) (×400).
Figure 2.
Figure 2.
The peripheral blood smear reveals a myeloid cell with several pink Auer rods (arrow) within the cytoplasm (×1000).
Figure 3.
Figure 3.
The peripheral blood smear reveals marked leukocytosis with predominant segmented neutrophils (circled in black). Rare blasts can also be identified (circled in red). One nucleated red blood cell is present (arrow) (×200).
Figure 4.
Figure 4.
The hematoxylin and eosin section of the bone marrow biopsy reveals a hypercellular marrow with numerous mature segmented neutrophils (circled in black) (×200).
Figure 5.
Figure 5.
The bone marrow aspirate smear reveals numerous blasts and 5 prominent mast cells, 1 with normal morphology (circled in black) and 4 of which are atypically spindle shaped (circled in red) (×400).
Figure 6.
Figure 6.
The hematoxylin and eosin section reveals a hypercellular marrow with gray aggregates of mast cells (circled in black) among neoplastic blasts (circled in red) (×200).
See this image and copyright information in PMC

References

    1. Knollmann-Ritschel BEC, Regula DP, Borowitz MJ, Conran R, Prystowsky MB. Pathology competencies for medical education and educational cases. Acad Pathol. 2017:4 doi:10.1177/2374289517715040. - PMC - PubMed
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    1. Hasserjian RP, Orazi A, Brunning RD, et al. Myelodysplastic syndromes: overview In: Swerdlow S, Campo E, Harris NL, eds. WHO Classification of Tumours of the Haematopoietic and Lymphoid Tissues Revised. 4th ed Lyon, France: IARC Press; 2017:97–105.
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