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Review
. 2021 Jul 4;29(5):1023-1028.
doi: 10.1080/09273948.2020.1726969. Epub 2020 Mar 11.

Cannabis and the Cornea

Anne X Nguyen  1 , Albert Y Wu  2
Affiliations
Review

Cannabis and the Cornea

Anne X Nguyen et al. Ocul Immunol Inflamm. .

Abstract

Purpose: While cannabis has the potential to reduce corneal pain, cannabinoids might induce side effects. This review article examines the effects of cannabinoids on the cornea. As more states and countries consider the legalization of adult cannabis use, health-care providers will need to identify ocular effects of cannabis consumption.Methods: Studies included in this review examined the connection between cannabis and the cornea, more specifically anti-nociceptive and anti-inflammatory actions of cannabinoids. NCBI Databases from 1781 up to December 2019 were consulted.Results: Five studies examined corneal dysfunctions caused by cannabis consumption (opacification, decreased endothelial cell density). Twelve studies observed a reduction in corneal pain and inflammation (less lymphocytes, decreased corneal neovascularization, increased cell proliferation and migration).Conclusion: More than half of the studies examined the therapeutic effects of cannabinoids on the cornea. As the field is still young, more studies should be conducted to develop safe cannabinoid treatments for corneal diseases.

Keywords: Cannabinoids; cannabis; cornea; corneal hyperalgesia; corneal inflammation.

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Conflict of interest statement

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Figures

Figure 1:
Figure 1:. Schematic Representations of Cannabinoid-Related Pathways
Cannabinoids bind to cannabinoid receptors, which are predominantly found in corneal epithelial cells and the basal ganglia. Non-cannabinoid receptors modulate the cerebral cannabinoid-signaling pathway involved in the regulation of ocular pain and inflammation.
See this image and copyright information in PMC

References

    1. Straiker AJ, Maguire G, Mackie K, Lindsey J. Localization of cannabinoid CB1 receptors in the human anterior eye and retina. Invest Ophthalmol Vis Sci. 1999;40(10):2442–2448. - PubMed
    1. Green K. The ocular effects of cannabinoids. Curr Top Eye Res. 1979;1:175–215. - PubMed
    1. Chen J, Matias I, Dinh T, et al. Finding of endocannabinoids in human eye tissues: implications for glaucoma. Biochem Biophys Res Commun. 2005;330(4):1062–1067. - PubMed
    1. Storozhuk MV, Zholos AV. TRP Channels as Novel Targets for Endogenous Ligands: Focus on Endocannabinoids and Nociceptive Signalling. Curr Neuropharmacol. 2018;16(2):137–150. - PMC - PubMed
    1. Toguri JT, Caldwell M, Kelly ME. Turning Down the Thermostat: Modulating the Endocannabinoid System in Ocular Inflammation and Pain. Front Pharmacol. 2016;7:304. - PMC - PubMed

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