Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Mar-Apr;83(2):160-167.
doi: 10.5935/0004-2749.20200037.

Clinical studies using stem cells for treatment of retinal diseases: state of the art

Carina Costa Cotrim  1 , Rodrigo Jorge  1 , Maria Carolina de Oliveira  2 , Fabiano Pieroni  3 , André M Vieira Messias  1 , Rubens Camargo Siqueira  1   4
Affiliations
Review

Clinical studies using stem cells for treatment of retinal diseases: state of the art

Carina Costa Cotrim et al. Arq Bras Oftalmol. 2020 Mar-Apr.

Abstract
in English, Portuguese

Degenerative retinal diseases such as retinitis pigmentosa, Stargardt's macular dystrophy, and age-related macular degeneration are characterized by irreversible loss of vision due to direct or indirect photoreceptor damage. No effective treatments exist, but stem cell studies have shown promising results. Our aim with this review was to describe the types of stem cells that are under study, their effects, and the main clinical trials involving them.

As doenças degenerativas da retina, como retinose pigmentar, distrofia macular de Stargardt e degeneração macular relaciona à idade, são caracterizadas por perda irre versível da visão devido a danos diretos ou indiretos aos fotorreceptores. Não existem tratamentos eficazes, porém os estudos com células-tronco mostraram resultados promissores. Nosso objetivo com esta revisão foi descrever os tipos de células-tronco em estudo, seus efeitos e os principais ensaios clínicos que as envolvem.

PubMed Disclaimer

Conflict of interest statement

Disclosure of potential conflicts of interest: None of the authors have any potential conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Schematic illustration off the various types of stem cells. 1, Embryonic stem cell; 2, retinal progenitor cells; 3, induced pluripotent stem cells (iPSCs); 4, bone marrow-derived hematopoietic stem cells. RPE (retinal pigment epithelium); 5, mesenchymal stem cell (MSC). Adipose tissue, umbilical cord, and bone marrow may originate MSC and HSCs. The main studies involving MSC are preclinical.
See this image and copyright information in PMC

References

    1. Öner A. Stem cell treatment in retinal diseases: recent developments. Turk J Ophthalmol. 2018;48(1):33–38. - PMC - PubMed
    1. Pellegrini G, De Luca M, Arsenijevic Y. Towards therapeutic application of ocular stem cells. Semin Cell Dev Biol. 2007;18(6):805–818. - PubMed
    1. Tibbetts MD, Samuel MA, Chang TS, Ho AC. Stem cell therapy for retinal disease. Curr Opin Ophthalmol. 2012;23(3):226–234. - PubMed
    1. Bauer G, Elsallab M, Abou-El-Enein M. Concise review: a comprehensive analysis of reported adverse events in patients receiving unproven stem cell-based interventions. Stem Cells Transl Med. 2018;7(9):676–685. - PMC - PubMed
    1. Siqueira R. Células tronco para tratamento de doenças da retina - Estudos clínicos. Rev Univ Vis. 2015;87:48–50.