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. 2020 Mar 11;15(3):e0230285.
doi: 10.1371/journal.pone.0230285. eCollection 2020.

High sPLA2-IIA level is associated with eicosanoid metabolism in patients with bacterial sepsis syndrome

Nurul Saadah Ahmad  1   2 , Toh Leong Tan  2 , Khaizurin Tajul Arifin  1 , Wan Zurinah Wan Ngah  1 , Yasmin Anum Mohd Yusof  3
Affiliations

High sPLA2-IIA level is associated with eicosanoid metabolism in patients with bacterial sepsis syndrome

Nurul Saadah Ahmad et al. PLoS One. .

Abstract

The aim of this study was to determine the association between secretory phospholipase A2 group IIA (sPLA2-IIA) and eicosanoid pathway metabolites in patients with bacterial sepsis syndrome (BSS). Levels of sPLA2-IIA, eicosanoids prostaglandin (PG)E2, PGD synthase were quantified in the sera from patients confirmed to have bacterial sepsis (BS; N = 45), bacterial severe sepsis/septic shock (BSS/SS; N = 35) and healthy subjects (N = 45). Cyclooxygenase (COX)-1 and COX-2 activities were analyzed from cell lysate. Serum levels of sPLA2-IIA, PGE2, and PGDS increased significantly in patients with BS and BSS/SS compared to healthy subjects (p<0.05). COX-2 activity was significantly increased in patients with BS compared to healthy subjects (p<0.05), but not COX-1 activity. Binary logistic regression analysis showed that sPLA2-IIA and PGE2 were independent factors predicting BSS severity. In conclusion, high level of sPLA2-IIA is associated with eicosanoid metabolism in patients with BSS.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Recruitment of research subjects.
See this image and copyright information in PMC

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