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. 2021 Nov;35(21):3745-3751.
doi: 10.1080/14786419.2020.1736061. Epub 2020 Mar 12.

Chevalierinol A and B, two new neolignan sesquiterpenoids from Magnolia chevalieri

Pham Thi Ninh  1   2 , Chu Thi Thu Ha  2   3 , Tran Huy Thai  2   3 , Nguyen Phuong Hanh  3 , Nguyen Sinh Khang  3 , Nguyen Thi Dung  1 , Ly Thi Thu Hoai  2   4 , Tran Van Chien  1   2 , Tran Van Loc  1   2 , Vo Thi Quynh Nhu  1 , Nguyen The Anh  1 , Trieu Quy Hung  5 , Tran Van Sung  1   2 , Ho Ngoc Anh  1 , Tran Thi Phuong Thao  1   2
Affiliations

Chevalierinol A and B, two new neolignan sesquiterpenoids from Magnolia chevalieri

Pham Thi Ninh et al. Nat Prod Res. 2021 Nov.

Abstract

Two new neolignan sesquiterpenoids, chevalierinol A (1) and chevalierinol B (2), were isolated from the ethyl acetate extract of Magnolia chevalieri leaves, together with twelve known compounds (3-14). Their structures were elucidated by analysis of spectroscopic data including 1D, 2D and mass spectra and compared with the reported data. Compounds 1, 3, 4, 6, 7, 10 were evaluated for their inhibitory effect against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophage cells.

Keywords: Magnolia chevalieri; chevalierinol A; chevalierinol B; neolignan; nitric oxide inhibitory activity; sesquiterpenoid.

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