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Case Reports
. 2020 Mar 1;66(3).
doi: 10.7754/Clin.Lab.2019.190606.

Identification of Amoxicillin Crystals in Urine: a Case Report

Alessandra Fanelli, Stefano Rapi, Stefano Dugheri, Alessandro Bonari, Eva Milletti, Giovanni Cappelli, Nicola Mucci, Giulio Arcangeli
Case Reports

Identification of Amoxicillin Crystals in Urine: a Case Report

Alessandra Fanelli et al. Clin Lab. .

Abstract

Background: The case concerns a 30-year-old woman in the 24th week of pregnancy presenting to the medical emergency room with fever and abdominal pain. Urine sediment microscopy revealed the presence of unknown needle-shaped crystals.

Methods: Crystals identification was performed by Fourier-Transform Infrared Spectroscopy coupled to Attenuated Total Reflectance (FTIR-ATR).

Results: Amoxicillin crystals were verified with semiquantitative results of 87.7%.

Conclusions: Drug-induced crystalluria is a frequent finding in urine examination and it may be asymptomatic. FTIR spectroscopy is a rapid and specific tool in identification of crystals and could be useful supporting renal disease diagnosis and monitoring drug therapy.

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