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Review
. 2020 Mar 12;10(2):345-363.
doi: 10.1002/cphy.c190013.

Orexin in Respiratory and Autonomic Regulation, Health and Diseases

Savannah Barnett  1 , Aihua Li  1
Affiliations
Review

Orexin in Respiratory and Autonomic Regulation, Health and Diseases

Savannah Barnett et al. Compr Physiol. .

Abstract

Orexin neurons, located in the hypothalamus, produce orexin-A and orexin-B neuropeptides and send widespread projections throughout the central nervous system, including many nuclei that are critically involved in sleep-wake, cardiorespiratory, and autonomic regulation. Significant progress has been made to better understand the roles of orexins in the control of breathing and autonomic functions since the discovery of orexins in 1998. Orexin neurons are CO2 /pH chemosensitive and blockade of orexin receptors with orexin receptor antagonists can significantly attenuate ventilatory response to hypercapnia or CO2 chemoreflex. Animal models with orexin abnormalities, for example, too little or too much, have all been reported to have significant alterations in breathing, central chemoreception (hypercapnic chemoreflex), blood pressure, thermoregulation, and cardiorespiratory responses to stress. More recent studies further show that abnormalities of the orexin system are linked to many neurological disorders in addition to narcolepsy, for example, sleep disorders, neurodegenerative disorders, neurogenic hypertension, and sudden infant death syndrome. These new findings have significantly advanced the knowledge in understanding the underlying mechanism of orexin-associated health and diseases while providing a new pathway for possible treatments. In this article, we will discuss some of the progresses in basic research and in health and diseases. © 2020 American Physiological Society. Compr Physiol 10:345-363, 2020.

Keywords: central chemoreception; control of breathing and autonomic functions; neurogenic diseases; orexin.

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References

    1. Abbott SB, Kanbar R, Bochorishvili G, Coates MB, Stornetta RL, Guyenet PG. C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats. J Physiol 590: 2897-2915, 2012. DOI: 10.1113/jphysiol.2012.232157.
    1. Akbari E, Motamedi F, Naghdi N, Noorbakhshnia M. The effect of antagonization of orexin 1 receptors in CA1 and dentate gyrus regions on memory processing in passive avoidance task. Behav Brain Res 187: 172-177, 2008. DOI: 10.1016/j.bbr.2007.09.019.
    1. Akbari E, Naghdi N, Motamedi F. The selective orexin 1 receptor antagonist SB-334867-A impairs acquisition and consolidation but not retrieval of spatial memory in Morris water maze. Peptides 28: 650-656, 2007. DOI: 10.1016/j.peptides.2006.11.002.
    1. Aksu K, Firat Guven S, Aksu F, Ciftci B, Ulukavak Ciftci T, Aksaray S, Sipit T, Peker Y. Obstructive sleep apnoea, cigarette smoking and plasma orexin-A in a sleep clinic cohort. J Int Med Res 37: 331-340, 2009. DOI: 10.1177/147323000903700207.
    1. Amin R, Simakajornboon N, Szczesniak R, Inge T. Early improvement in obstructive sleep apnea and increase in orexin levels after bariatric surgery in adolescents and young adults. Surg Obes Relat Dis 13: 95-100, 2017. DOI: 10.1016/j.soard.2016.05.023.

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