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. 2020 Mar 12;20(1):131.
doi: 10.1186/s12872-020-01409-0.

Assessing left ventricular systolic function in children with a history of Kawasaki disease

Zhou Lin  1 , Jingjing Zheng  1 , Weiling Chen  1 , Tingting Ding  1 , Wei Yu  1 , Bei Xia  2
Affiliations

Assessing left ventricular systolic function in children with a history of Kawasaki disease

Zhou Lin et al. BMC Cardiovasc Disord. .

Abstract

Background: The incidence of Kawasaki disease (KD) is increasing. Indeed, KD has become the most common cause of acquired heart disease in children. Previous studies have well summarized the acute phase left ventricular (LV) systolic dysfunction using speckle tracking echocardiography (STE); however, changes in LV systolic function after long-term follow-up remain unclear.

Methods: One hundred children with a history of KD, but without coronary artery aneurysms, were enrolled. These children were divided into two subgroups based on the presence or absence of coronary artery dilatation (CAD). The duration of follow-up was > 7 years. The control group consisted of 51 healthy children. The LV myocardial strain were measured by two- and three-dimensional STE.

Results: Two-dimensional STE not only revealed that LV longitudinal strain decreased in part of segments in both KD groups, but also showed that global strain decreased in the KD group with CAD compared to the controls (P < 0.05). Global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), and global area strain (GAS) were obtained by 3D STE. Compared to the controls, GLS and GAS decreased in both KD groups (P < 0.05). GCS and GRS decreased in the KD group with CAD, but was unchanged in the KD group without CAD (P < 0.05).

Conclusions: LV systolic dysfunction in children with KD and CAD was more severe than KD children without CAD compared to healthy children. This dysfunction can be assessed by LV regional and global myocardial strain using two- and three-dimensional STE.

Keywords: Follow-up; Kawasaki disease; Long-term; Speckle tacking echocardiography.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The difference of GLS between the KD with CAD group, KD without CAD group and the control group. a KD with CAD patient. b KD without CAD patient. c normal children. CAD: coronary artery dilation; GLS: global longitudinal strain; KD: Kawasaki disease
See this image and copyright information in PMC

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