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. 2020:45:199-474.
doi: 10.1016/bs.podrm.2019.10.007. Epub 2019 Dec 18.

Piroxicam

Gamal A E Mostafa  1 , Abdullah S Al-Dosseri  1 , Abdullah A Al-Badr  1
Affiliations

Piroxicam

Gamal A E Mostafa et al. Profiles Drug Subst Excip Relat Methodol. 2020.

Abstract

A comprehensive profile of piroxicam including the nomenclatures, formulae, elemental composition, appearance, uses and applications. The methods which were utilized for the preparation of the drug substance and their respective schemes are outlined. The physical characteristics of the drug including the ionization constant, solubility, x-ray powder diffraction pattern, differential scanning calorimetry, thermal behavior and spectroscopic studies are described. The methods which were used for the analysis of the drug substance in bulk drug and/or in pharmaceutical formulations including the compendial, spectrophotometric, electrochemical and the chromatographic methods are reported. The stability, toxicity, pharmacokinetics, bioavailability, drug evaluation, comparison, in addition to compiled reviews on the drug substance are involved. Finally, more than four hundred and fifty references are listed at the end of this profile.

Keywords: Biological investigations; Description; Methods of analysis; Methods of preparation; Physical characteristics; Piroxicam; Stability; Toxicity and reviews.

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