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. 2020:45:41-53.
doi: 10.1016/bs.podrm.2019.10.002. Epub 2019 Dec 5.

Carbetapentane citrate

Ahmed S Abo Dena  1 , Alaa M Ali  2 , Ibrahim M El-Sherbiny  2
Affiliations

Carbetapentane citrate

Ahmed S Abo Dena et al. Profiles Drug Subst Excip Relat Methodol. 2020.

Abstract

Carbetapentane citrate, a non-opioid centrally-acting antitussive drug, is a common treatment for cough associated with other diseases such as common cold and respiratory tract infections. Its mode of action is very close to that of atropine; since it acts at the level of the peripheral parasympathetic nerve endings. The drug reaches its maximum plasma concentration (Cmax) 2h after administration, and it has a plasma half-life of 2.3h in case of oral administration. Due to its clinical importance, there are many analytical methods in the literature for carbetapentane determination. In addition, it is crucial to collect its analytical results in a single chapter so as to allow researchers to easily interpret their experimental data. Here, we provide the analytical profile of carbetapentane citrate with a brief description/interpretation of each analysis.

Keywords: Analytical methods; Antitussive; Carbetapentane; Cough suppressant; FTIR; NMR; Pentoxyverine; Thermal analysis; UV spectroscopy.

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