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Case Reports
. 2020 Mar-Apr;95(2):241-243.
doi: 10.1016/j.abd.2019.04.015. Epub 2020 Feb 12.

Therapeutic failure with itraconazole in sporotrichosis due to bariatric surgery

Larissa Crestani  1 , Bruno de Castro E Souza  2 , Priscila Kakizaki  2 , Neusa Yuriko Sakai Valente  2
Affiliations
Case Reports

Therapeutic failure with itraconazole in sporotrichosis due to bariatric surgery

Larissa Crestani et al. An Bras Dermatol. 2020 Mar-Apr.

Abstract

Sporotrichosis is a deep mycosis of subacute or chronic evolution, caused by the dimorphic fungus of the genus Sporothrix. The treatment is carried out with antifungal orally or intravenously. Therapeutic success can be affected by several factors, such as altered gastrointestinal physiology by surgery. More and more patients are submitted to bariatric surgeries and the literature for the alterations of the absorption of medications in this context is very scarce. We intend to contribute to a better understanding with this case report of cutaneous-lymphatic sporotrichosis in a patient after bariatric surgery without response to itraconazole treatment, even at high doses.

Keywords: Bariatric surgery; Itraconazole; Sporotrichosis; Treatment failure.

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Figures

Figure 1
Figure 1
Clinical picture prior to treatment with terbinafine. Nodules approximately 2 cm in diameter, discretely erythematous that followed the lymphatic drainage pathway of the right upper limb. In some lesions there was formation of central ulcers.
Figure 2
Figure 2
Culture in Sabouraud agar medium.
Figure 3
Figure 3
Clinical picture after finishing treatment. Complete regression of lesions.
See this image and copyright information in PMC

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