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Review
. 2020 Apr;48(2):74-82.
doi: 10.1249/JES.0000000000000219.

Pro-opiomelanocortin Neurons and the Transcriptional Regulation of Motivated Exercise

Deborah J Good  1 , Haiyan Zhang  1 , Robert W Grange  1 , Thomas Braun  2
Affiliations
Review

Pro-opiomelanocortin Neurons and the Transcriptional Regulation of Motivated Exercise

Deborah J Good et al. Exerc Sport Sci Rev. 2020 Apr.

Abstract

Hypothalamic pro-opiomelanocortin (POMC) neurons are key sensory neurons for energy balance. The basic helix-loop-helix transcription factor NHLH2 is expressed in POMC neurons, and Nhlh2 knockout mice show adult-onset obesity with low exercise behavior. Evidence is presented to explore the hypothesis that NHLH2 transcriptional activity within POMC neurons is crucial for maintaining motivated spontaneous activity and enforced exercise.

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