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Comment
. 2020 Apr;45(4):276-278.
doi: 10.1016/j.tibs.2020.01.007. Epub 2020 Feb 17.

The Structure of ASFV Advances the Fight against the Disease

Yuejiao Xian  1 , Chuan Xiao  2
Affiliations
Comment

The Structure of ASFV Advances the Fight against the Disease

Yuejiao Xian et al. Trends Biochem Sci. 2020 Apr.

Abstract

African swine fever virus (ASFV) is the causative pathogen of the recent African swine fever epidemic, with devastating impacts on economy. A recent study by Wang et al. reveals the multilayer structural details of ASFV at near-atomic resolution, which provides interesting insights about giant virus assembly and paves the way for vaccine development.

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Figures

Figure 1.
Figure 1.. The Multilayer Architecture of African Swine Fever Virus (ASFV).
The five layers, including the genome core, nucleocapsid, inner membrane, capsid, and outer membrane, are colored in red, orange, green, blue, and grey, respectively. For a better observation on the capsid, the outer membrane has been depicted with 70% transparency. The capsid surface was colored by pentasymmetrons (dark blue) and trisymmetrons (lighter blue colors including cyan, dodger blue, and cornflower blue).
See this image and copyright information in PMC

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References

    1. Zhou L (2019) African swine fever epidemic in China. Vet. Rec 184, 713. - PubMed
    1. Zhu D et al. (2018) Pushing the resolution limit by correcting the Ewald sphere effect in single-particle cryo-EM reconstructions. Nat. Commun 9, 1552. - PMC - PubMed
    1. Fang Q et al. (2019) Near-atomic structure of a giant virus. Nat. Commun 10, 388. - PMC - PubMed
    1. Wang N et al. (2019) Architecture of African swine fever virus and implications for viral assembly. Science 366, 640–644 - PubMed
    1. Xiao C et al. (2017) Cryo-EM reconstruction of the Cafeteria roenbergensis virus capsid suggests novel assembly pathway for giant viruses. Sci. Rep 7, 5484. - PMC - PubMed

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