Current Approaches to the Pharmacologic Treatment of Core Symptoms Across the Lifespan of Autism Spectrum Disorder
- PMID: 32169264
- DOI: 10.1016/j.chc.2019.12.004
Current Approaches to the Pharmacologic Treatment of Core Symptoms Across the Lifespan of Autism Spectrum Disorder
Abstract
There are no approved medications for autism spectrum disorder (ASD) core symptoms. However, given the significant clinical need, children and adults with ASD are prescribed medication off label for core or associated conditions, sometimes based on limited evidence for effectiveness. Recent developments in the understanding of biologic basis of ASD have led to novel targets with potential to impact core symptoms, and several clinical trials are underway. Heterogeneity in course of development, co-occurring conditions, and age-related treatment response variability hampers study outcomes. Novel measures and approaches to ASD clinical trial design will help in development of effective pharmacologic treatments.
Keywords: ASD; Autism; Clinical trials; Drug development; Therapeutics.
Copyright © 2020 Elsevier Inc. All rights reserved.
Conflict of interest statement
Disclosure statement R.H. Ring works for a company involved in the discovery and development of therapeutics for genetic syndromes that cause autism. The company is a research company and has no commercial products of any kind. G. Pandina, A. Bangerter, and S. Ness are full-time employees and stockholders at Janssen Research & Development, LLC.
Republished in
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Current Approaches to the Pharmacologic Treatment of Core Symptoms Across the Lifespan of Autism Spectrum Disorder.Psychiatr Clin North Am. 2020 Dec;43(4):629-645. doi: 10.1016/j.psc.2020.08.003. Psychiatr Clin North Am. 2020. PMID: 33126999 Review.
