Colibactin Causes Colorectal Cancer-Associated Mutational Signature

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No authors listed. Cancer Discov. 2020 May.

. 2020 May;10(5):635.

doi: 10.1158/2159-8290.CD-RW2020-037. Epub 2020 Mar 13.

Abstract

The pks ⁺ E. coli metabolite colibactin caused a unique mutational signature in intestinal organoids.

Mutational signature in colorectal cancer caused by genotoxic pks⁺ E. coli.
Pleguezuelos-Manzano C, Puschhof J, Rosendahl Huber A, van Hoeck A, Wood HM, Nomburg J, Gurjao C, Manders F, Dalmasso G, Stege PB, Paganelli FL, Geurts MH, Beumer J, Mizutani T, Miao Y, van der Linden R, van der Elst S; Genomics England Research Consortium; Garcia KC, Top J, Willems RJL, Giannakis M, Bonnet R, Quirke P, Meyerson M, Cuppen E, van Boxtel R, Clevers H. Pleguezuelos-Manzano C, et al. Nature. 2020 Apr;580(7802):269-273. doi: 10.1038/s41586-020-2080-8. Epub 2020 Feb 27. Nature. 2020. PMID: 32106218 Free PMC article.