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Review
. 2020 May 21;33(6):482-490.
doi: 10.1093/ajh/hpaa038.

Is the Brain an Early or Late Component of Essential Hypertension?

John Richard Jennings  1 , Matthew F Muldoon  2   3 , Alan F Sved  4   5
Affiliations
Review

Is the Brain an Early or Late Component of Essential Hypertension?

John Richard Jennings et al. Am J Hypertens. .

Abstract

The brain's relationship to essential hypertension is primarily understood to be that of an end-organ, damaged late in life by stroke or dementia. Emerging evidence, however, shows that heightened blood pressure (BP) early in life and prior to traditionally defined hypertension, relates to altered brain structure, cerebrovascular function, and cognitive processing. Deficits in cognitive function, cerebral blood flow responsivity, volumes of brain areas, and white matter integrity all relate to increased but prehypertensive levels of BP. Such relationships may be observed as early as childhood. In this review, we consider the basis of these relationships by examining the emergence of putative causative factors for hypertension that would impact or involve brain function/structure, e.g., sympathetic nervous system activation and related endocrine and inflammatory activation. Currently, however, available evidence is not sufficient to fully explain the specific pattern of brain deficits related to heightened BP. Despite this uncertainty, the evidence reviewed suggests the value that early intervention may have, not only for reducing BP, but also for maintaining brain function.

Keywords: blood pressure; brain; brain imaging; dementia; hypertension; neuropsychology; stress.

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Figures

Figure 1.
Figure 1.
Diagram of possible relation of brain, blood pressure, and renal/vasculature progression.
See this image and copyright information in PMC

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