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Multicenter Study
. 2021 Jan;36(1):121-130.
doi: 10.1007/s12928-020-00658-2. Epub 2020 Mar 13.

Clinical outcome after surgical aortic valve replacement in low-risk Japanese patients with severe aortic stenosis

Yasuaki Takeji  1 , Tomohiko Taniguchi  2 , Takeshi Morimoto  3 , Naritatsu Saito  1 , Kenji Ando  2 , Shinichi Shirai  2 , Yuichi Kawase  4 , Takeshi Kitai  5 , Hiroki Shiomi  1 , Eri Minamino-Muta  1 , Shintaro Matsuda  1 , Kazuhiro Yamazaki  6 , Makoto Miyake  7 , Koichiro Murata  8 , Norio Kanamori  9 , Chisato Izumi  10 , Hirokazu Mitsuoka  11 , Masashi Kato  12 , Yutaka Hirano  13 , Tsukasa Inada  14 , Kazuya Nagao  14 , Hiroshi Mabuchi  15 , Yasuyo Takeuchi  16 , Keiichiro Yamane  17 , Mamoru Toyofuku  18 , Mitsuru Ishii  19 , Moriaki Inoko  20 , Tomoyuki Ikeda  21 , Katsuhisa Ishii  22 , Kozo Hotta  23 , Toshikazu Jinnai  24 , Nobuya Higashitani  24 , Yoshihiro Kato  25 , Yasutaka Inuzuka  26 , Yuko Morikami  27 , Kenji Minatoya  6 , Takeshi Kimura  28 ; CURRENT AS registry Investigators
Affiliations
Multicenter Study

Clinical outcome after surgical aortic valve replacement in low-risk Japanese patients with severe aortic stenosis

Yasuaki Takeji et al. Cardiovasc Interv Ther. 2021 Jan.

Abstract

Two randomized control trials demonstrated that transcatheter aortic valve implantation was associated with 1-2 year clinical outcomes comparable or even superior to surgical aortic valve replacement (SAVR) in low surgical risk patients with severe aortic stenosis (AS). However, no previous study has reported the clinical outcomes after SAVR in Japanese patients with low surgical risk. From 3815 consecutive patients enrolled in the CURRENT AS registry, we retrieved 220 patients who underwent SAVR in reference to the inclusion and exclusion criteria of the PARTNER 3 trial. Age and surgical risk score in the current study population were comparable to those in the PARTNER 3 trial (Age: 75 years versus 74 years, and STS-PROM score: 2.3 versus 1.9). The cumulative incidence of a composite all-cause death or stroke was comparable between the current study population and the SAVR patients in the PARTNER 3 trial both at 30-day (2.3% versus 3.3%), and at 1-year (4.1% versus 4.9%). The clinical outcomes of SAVR in low surgical risk patients with severe AS selected from a real world Japanese registry according to the inclusion and exclusion criteria of the PARTNER 3 trial was favorable and numerically comparable to those of SAVR patients in the PARTNER 3 trial.

Keywords: Aortic stenosis; Surgical aortic valve replacement.

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