Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

Lei Fang¹, George Karakiulakis², Michael Roth³

Affiliations

¹ Pulmonary Cell Research and Pneumology, Department of Biomedicine and Internal Medicine, University Hospital Basel, CH-4031 Basel, Switzerland.
² Department of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
³ Pulmonary Cell Research and Pneumology, Department of Biomedicine and Internal Medicine, University Hospital Basel, CH-4031 Basel, Switzerland. Electronic address: michael.roth@usb.ch.

PMID: 32171062
PMCID: PMC7118626
DOI: 10.1016/S2213-2600(20)30116-8

Comment

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

Lei Fang et al. Lancet Respir Med. 2020 Apr.

. 2020 Apr;8(4):e21.

doi: 10.1016/S2213-2600(20)30116-8. Epub 2020 Mar 11.

Authors

Lei Fang¹, George Karakiulakis², Michael Roth³

Affiliations

¹ Pulmonary Cell Research and Pneumology, Department of Biomedicine and Internal Medicine, University Hospital Basel, CH-4031 Basel, Switzerland.
² Department of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
³ Pulmonary Cell Research and Pneumology, Department of Biomedicine and Internal Medicine, University Hospital Basel, CH-4031 Basel, Switzerland. Electronic address: michael.roth@usb.ch.

PMID: 32171062
PMCID: PMC7118626
DOI: 10.1016/S2213-2600(20)30116-8

Erratum in

Correction to Lancet Respir Med 2020; 8: e21.
[No authors listed] [No authors listed] Lancet Respir Med. 2020 Jun;8(6):e54. doi: 10.1016/S2213-2600(20)30235-6. Epub 2020 May 18. Lancet Respir Med. 2020. PMID: 32437647 Free PMC article. No abstract available.

No abstract available

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Comment in

Antihypertensive drugs and risk of COVID-19?
Tignanelli CJ, Ingraham NE, Sparks MA, Reilkoff R, Bezdicek T, Benson B, Schacker T, Chipman JG, Puskarich MA. Tignanelli CJ, et al. Lancet Respir Med. 2020 May;8(5):e30-e31. doi: 10.1016/S2213-2600(20)30153-3. Epub 2020 Mar 26. Lancet Respir Med. 2020. PMID: 32222166 Free PMC article. No abstract available.
Antihypertensive drugs and risk of COVID-19?
Lo KB, McCullough PA, Rangaswami J. Lo KB, et al. Lancet Respir Med. 2020 May;8(5):e29. doi: 10.1016/S2213-2600(20)30156-9. Epub 2020 Mar 26. Lancet Respir Med. 2020. PMID: 32222167 Free PMC article. No abstract available.
Antihypertensive drugs and risk of COVID-19?
Brown JD. Brown JD. Lancet Respir Med. 2020 May;8(5):e28. doi: 10.1016/S2213-2600(20)30158-2. Epub 2020 Mar 26. Lancet Respir Med. 2020. PMID: 32222168 Free PMC article. No abstract available.
Antihypertensive drugs and risk of COVID-19? - Authors' reply.
Fang L, Karakiulakis G, Roth M. Fang L, et al. Lancet Respir Med. 2020 May;8(5):e32-e33. doi: 10.1016/S2213-2600(20)30159-4. Epub 2020 Mar 26. Lancet Respir Med. 2020. PMID: 32222169 Free PMC article. No abstract available.
Speculation is not evidence: antihypertensive therapy and COVID-19.
de Simone G, Mancusi C. de Simone G, et al. Eur Heart J Cardiovasc Pharmacother. 2020 Jul 1;6(3):133-134. doi: 10.1093/ehjcvp/pvaa021. Eur Heart J Cardiovasc Pharmacother. 2020. PMID: 32236478 Free PMC article. No abstract available.
Warning Against the Use of Anti-Inflammatory Medicines to Cure COVID-19: Building Castles in the Air.
Varrassi G. Varrassi G. Adv Ther. 2020 May;37(5):1705-1707. doi: 10.1007/s12325-020-01321-1. Epub 2020 Apr 1. Adv Ther. 2020. PMID: 32239459 Free PMC article. No abstract available.
Should Patients Receiving ACE Inhibitors or Angiotensin Receptor Blockers be Switched to Other Antihypertensive Drugs to Prevent or Improve Prognosis of Novel Coronavirus Disease 2019 (COVID-19)?
Trifirò G, Crisafulli S, Andò G, Racagni G, Drago F; Italian Society of Pharmacology. Trifirò G, et al. Drug Saf. 2020 Jun;43(6):507-509. doi: 10.1007/s40264-020-00935-2. Drug Saf. 2020. PMID: 32303915 Free PMC article. No abstract available.
Response to recent commentaries regarding the involvement of angiotensin-converting enzyme 2 (ACE2) and renin-angiotensin system blockers in SARS-CoV-2 infections.
Speth RC. Speth RC. Drug Dev Res. 2020 Sep;81(6):643-646. doi: 10.1002/ddr.21672. Epub 2020 Apr 17. Drug Dev Res. 2020. PMID: 32304146 Free PMC article. No abstract available.
Angiotensin receptor blockers and COVID-19.
Saavedra JM. Saavedra JM. Pharmacol Res. 2020 Jun;156:104832. doi: 10.1016/j.phrs.2020.104832. Epub 2020 Apr 15. Pharmacol Res. 2020. PMID: 32304747 Free PMC article.
No adequate evidence indicating hypertension as an independent risk factor for COVID-19 severity.
Li G, Li H, Lu J. Li G, et al. Clin Res Cardiol. 2021 Jan;110(1):146-147. doi: 10.1007/s00392-020-01653-6. Epub 2020 Apr 23. Clin Res Cardiol. 2021. PMID: 32328736 Free PMC article. No abstract available.
Deprescribing in the time of covid-19.
Phizackerley D. Phizackerley D. Drug Ther Bull. 2020 Jun;58(6):82. doi: 10.1136/dtb.2020.000027. Epub 2020 Apr 30. Drug Ther Bull. 2020. PMID: 32354724 No abstract available.
Could patients taking isotretinoin therapy be immune against SARS-CoV-2?
Hamouda Elgarhy L. Hamouda Elgarhy L. Dermatol Ther. 2020 Jul;33(4):e13573. doi: 10.1111/dth.13573. Epub 2020 May 29. Dermatol Ther. 2020. PMID: 32406143 Free PMC article. No abstract available.
NSAIDs for analgesia in the era of COVID-19.
Herzberg DL, Sukumaran HP, Viscusi E. Herzberg DL, et al. Reg Anesth Pain Med. 2020 Sep;45(9):677-678. doi: 10.1136/rapm-2020-101584. Epub 2020 Jun 3. Reg Anesth Pain Med. 2020. PMID: 32499385 Free PMC article.
No current evidence supporting risk of using Ibuprofen in patients with COVID-19.
Martins-Filho PR, do Nascimento-Júnior EM, Santos VS. Martins-Filho PR, et al. Int J Clin Pract. 2020 Oct;74(10):e13576. doi: 10.1111/ijcp.13576. Int J Clin Pract. 2020. PMID: 32506743 Free PMC article. No abstract available.

Comment on

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, Wu Y, Zhang L, Yu Z, Fang M, Yu T, Wang Y, Pan S, Zou X, Yuan S, Shang Y. Yang X, et al. Lancet Respir Med. 2020 May;8(5):475-481. doi: 10.1016/S2213-2600(20)30079-5. Epub 2020 Feb 24. Lancet Respir Med. 2020. PMID: 32105632 Free PMC article.

References

1. Yang X, Yu Y, Xu J. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020 doi: 10.1016/S2213-2600(20)30079-5. published online Feb 24. - DOI - PMC - PubMed
1. Guan W, Ni Z, Hu Y. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020 doi: 10.1056/NEJMoa2002032. published online Feb 28. - DOI - PMC - PubMed
1. Zhang JJ, Dong X, Cao YY. Clinical characteristics of 140 patients infected by SARS-CoV-2 in Wuhan, China. Allergy. 2020 doi: 10.1111/all.14238. published online Feb 19. - DOI - PubMed
1. Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS. J Virology. 2020 doi: 10.1128/JVI.00127-20. published online Jan 29. - DOI - PMC - PubMed
1. Li XC, Zhang J, Zhuo JL. The vasoprotective axes of the renin-angiotensin system: physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases. Pharmacol Res. 2017;125:21–38. - PMC - PubMed

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Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

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Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

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