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. 2020 Mar 14;20(1):220.
doi: 10.1186/s12885-020-6711-0.

Adult primary testicular lymphoma: clinical features and survival in a series of patients treated at a high-volume institution in China

Bo Chen  1   2 , De-Hong Cao  1   2 , Li Lai  1 , Jian-Bing Guo  1   2 , Ze-Yu Chen  1   2 , Yin Huang  1   2 , Shi Qiu  1   2 , Tian-Hai Lin  1   2 , Yue Gou  3 , Na Ma  4 , Lu Yang  1   2 , Liang-Ren Liu  5   6 , Qiang Wei  7   8
Affiliations

Adult primary testicular lymphoma: clinical features and survival in a series of patients treated at a high-volume institution in China

Bo Chen et al. BMC Cancer. .

Abstract

Background: To retrospectively investigate the clinical characteristics, initial treatment, relapse, therapy outcome, and prognosis of Chinese patients with primary testicular lymphoma (PTL) through analysis of the cases of our institute.

Methods: From December 2008 to July 2018, all patients with PTL were included in this study. Kaplan-Meier method was used to estimate PFS and OS. The Cox proportional hazards model was used to compare the survival times for groups of patients differing in terms of clinical and laboratory parameters.

Results: All 28 PTL patients (24 DLBCL, three NK/T lymphomas, and one Burkkit's lymphoma) with a median age of 65.5 years were included in this study. Six patients were observed recurrence among all the 22 individuals evaluated. Following orchiectomy and systemic chemotherapy, with or without intrathecal prophylaxis, complete response was achieved in 15 (68%) patients. For DLBCL patients, the median progression-free survival (PFS) was 44.63 months (95% CI 17.71-71.56 months), and the median overall survival (OS) was 77.02 months (95% CI, 57.35-96.69 months). For all the DLBCL patients, the 5-year PFS and 5-year OS were 35.4% (95%CI, 14.8-56.0%) and 53.4% (95%CI, 30.1-76.7%). Without further chemotherapy following orchiectomy (HR = 3.4, P = 0.03) were associated with inferior PFS of DLBCL patients. Advanced Ann Arbor stage (HR =5.9, P = 0.009) and high (international prognostic index, IPI) score: 3-5 (HR =3.9, P = 0.04) were correlated with shorter OS of DLBCL patients.

Conclusion: This study confirms that PTL is an aggressive malignant with a poor prognosis. Limited Ann Arbor stage, further chemotherapy following orchiectomy, and low IPI score (less than 2) are correlated with superior survival for DLBCL patients.

Keywords: Diffuse large B-cell lymphoma; Primary testicular lymphoma; Testis.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Kaplan-Meier survival curves showing (a) progression-free survival (PFS) and (b) overall survival (OS) of DLBCL patients
Fig. 2
Fig. 2
Kaplan-Meier survival curves showing overall survival (OS) of DLBCL patients by Ann Arbor stage
Fig. 3
Fig. 3
Kaplan-Meier survival curves showing overall survival (OS) of DLBCL patients by international prognostic index (IPI) score
See this image and copyright information in PMC

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