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. 2020 Mar 15:26:e919435.
doi: 10.12659/MSM.919435.

Drug-Induced Liver Injury: Clinical and Etiologic Features at a Large Tertiary Teaching Hospital in China

Yao Liu  1 , Shi-Peng Zhan  1 , Lin Song  2 , Yonggang Chen  2 , Yun-Tao Jia  2 , Fang Liu  1 , Feng-Jun Sun  1 , Qian Wang  1 , Pei-Yuan Xia  1
Affiliations

Drug-Induced Liver Injury: Clinical and Etiologic Features at a Large Tertiary Teaching Hospital in China

Yao Liu et al. Med Sci Monit. .

Abstract

BACKGROUND Since the epidemiological profile of drug-induced liver injury (DILI) in China, especially the western of China, it has rarely been studied. The aim of this study was to analyze the characteristics of DILI patients in a large tertiary teaching hospital at Chongqing, a municipality in western China. MATERIAL AND METHODS The medical records of hospitalized patients which diagnosed with DILI between January 2011 and December 2016 were searched retrospectively, and demographic, clinical data, and laboratory data were retrieved for analysis. RESULTS A total of 1811 patients had been diagnosed with DILI, accounting for 0.248% of the total admissions during the same period. Among the 1096 patients included in our analysis, DILI was caused by "medications" in 462 cases (42.15%), "herbs" in 391 cases (35.68%), and combined medications in 189 cases (17.24%). The profiles for each etiology were distinctive for age, sex, clinical features, laboratory features, and types and severity of DILI. CONCLUSIONS Our study provides a systematic etiological profile of DILI in Chinese patients, which can represent references for prevention, diagnosis and treatment, supporting and promoting efforts to ease the burden of this liver disease in China.

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Conflict of interest statement

Conflicts of interest

None.

Figures

Figure 1
Figure 1
Age distribution of 1096 cases of drug-induced liver injury.
Figure 2
Figure 2
Causative drugs in 1096 cases of drug-induced liver injury (DILI) according to drug class and possibility of injury.
Figure 3
Figure 3
Distribution of drug-induced liver injury (DILI) cases with different etiologies according to types of DILI.
Figure 4
Figure 4
Distribution of drug-induced liver injury (DILI) cases with different etiologies according to severity of DILI.
See this image and copyright information in PMC

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