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Review
. 2020 May;127(5):785-791.
doi: 10.1007/s00702-020-02167-1. Epub 2020 Mar 14.

Parkinson's disease treatment: past, present, and future

John D Elsworth  1
Affiliations
Review

Parkinson's disease treatment: past, present, and future

John D Elsworth. J Neural Transm (Vienna). 2020 May.

Abstract

The substantial contributions of Dr. Gerald Stern to past and current treatments for Parkinson's disease patients are reviewed, which form the foundation for an evaluation of future options to control symptoms and halt progression of the disease. These opportunities will depend on a greater understanding of the relative contributions of the environment, genetic and epigenetic influences to disease onset, and promise to emerge as strategies for improving mitochondrial function, halting accumulation of synuclein and neuromelanin, in addition to refinement of stem cell and gene therapies. Such advances will be achieved through deployment of improved models for the disease.

Keywords: Gene therapy; Parkinson’s disease; Pathology; Pharmacology; Review; Stem cells.

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Conflict of interest statement

Conflict of interest: The author has no financial disclosure to make or have any conflict of interest.

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