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Review
. 2020 Apr;36(2):189-200.
doi: 10.1016/j.ccc.2019.11.001. Epub 2020 Jan 31.

Cell-Cell Communication Breakdown and Endothelial Dysfunction

Daniel D Lee  1 , Margaret A Schwarz  2
Affiliations
Review

Cell-Cell Communication Breakdown and Endothelial Dysfunction

Daniel D Lee et al. Crit Care Clin. 2020 Apr.

Abstract

Guided by organ-specific signals in both development and disease response, the heterogeneous endothelial cell population is a dynamic member of the vasculature. Functioning as the gatekeeper to fluid, inflammatory cells, oxygen, and nutrients, endothelial cell communication with its local environment is critical. Impairment of endothelial cell-cell communication not only disrupts this signaling process, but also contributes to pathologic disease progression. Expanding our understanding of those processes that mediate endothelial cell-cell communication is an important step in the approach to treatment of disease processes.

Keywords: Development; Disease; Dysfunction; Endothelium; Heterogeneity; Signaling.

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Conflict of interest statement

Disclosure There are no commercial or financial conflicts of interest for the authors.

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