Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Apr;36(2):255-265.
doi: 10.1016/j.ccc.2019.12.002. Epub 2020 Jan 31.

Role of Antithrombin III and Tissue Factor Pathway in the Pathogenesis of Sepsis

Sarah Sungurlu  1 , Jessica Kuppy  1 , Robert A Balk  2
Affiliations
Review

Role of Antithrombin III and Tissue Factor Pathway in the Pathogenesis of Sepsis

Sarah Sungurlu et al. Crit Care Clin. 2020 Apr.

Abstract

The pathobiology of the septic process includes a complex interrelationship between inflammation and the coagulations system. Antithrombin (AT) and tissue factor are important components of the coagulation system and have potential roles in the production and amplification of sepsis. Sepsis is associated with a decrease in AT levels, and low levels are also associated with the development of multiple organ failure and death. Treatment strategies incorporating AT replacement therapy in sepsis and septic shock have not resulted in an improvement in survival or reversal of disseminated intravascular coagulation.

Keywords: Antithrombin; Coagulopathy; Multiple organ failure; Sepsis; Tissue factor.

PubMed Disclaimer

Conflict of interest statement

Disclosure The authors have no significant relationships to disclose related to this article.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles