Microvascular Dysfunction in the Critically Ill
- PMID: 32172816
- DOI: 10.1016/j.ccc.2019.11.003
Microvascular Dysfunction in the Critically Ill
Abstract
Microvascular dysfunction is a frequent complication of many chronic and acute conditions, especially in the critically ill. Moreover, the severity of microvascular alterations is associated with development of organ dysfunction and poor outcome. The complexities and heterogeneity of critical illness, especially in the elderly patient, requires more mechanistically oriented clinical trials that monitor the effectiveness of existing therapies and of those to come. Recent advances in the ability to obtain physiologically based assessments of microcirculatory function at the bedside will make microcirculatory-guided resuscitation a point of care reality.
Keywords: Aging; Critical illness; Endothelium; Lymphatics; Microcirculation.
Copyright © 2019 Elsevier Inc. All rights reserved.
Conflict of interest statement
Disclosure Dr Ince and his team provide training and educational services related to performing clinical sublingual microcirculation measurements described in this paper. To this purpose, he runs an Internet site called https://www.microcirculationacademy.org, where also the automatic software for analysis of microcirculation images called MicroTools is made available. The Internet site and its activities are run by a company called Active Medical BV of which he owns shares. Dr De Backer and Dr Mayeux have nothing to disclose.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
