Photopolymerized Starchstarch Nanoparticle (SNP) network hydrogels

Michael J Majcher¹, Carter L McInnis², Sebastian Himbert³, Richard J Alsop⁴, Dennis Kinio⁵, Markus Bleuel⁶, Maikel C Rheinstädter⁷, Niels M B Smeets⁸, Todd Hoare⁹

Affiliations

¹ Department of Chemical Engineering, McMaster University, 1280 Main Street, West Hamilton, ON L8S 4L8, Canada. Electronic address: majcherm@mcmaster.ca.
² Department of Chemical Engineering, McMaster University, 1280 Main Street, West Hamilton, ON L8S 4L8, Canada. Electronic address: carter.l.mcinnis@gmail.com.
³ Department of Physics and Astronomy, McMaster University, 1280 Main Street, West Hamilton, ON L8S 4L8, Canada. Electronic address: himberts@mcmaster.ca.
⁴ Department of Physics and Astronomy, McMaster University, 1280 Main Street, West Hamilton, ON L8S 4L8, Canada. Electronic address: alsoprj@mcmaster.ca.
⁵ EcoSynthetix Inc., 3365 Mainway, Burlington, ON L7M 1A6, Canada. Electronic address: dkinio@ecosynthetix.onmicrosoft.com.
⁶ NIST Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899-6100, United States. Electronic address: markus.bleuel@nist.gov.
⁷ Department of Physics and Astronomy, McMaster University, 1280 Main Street, West Hamilton, ON L8S 4L8, Canada. Electronic address: rheinsm@mcmaster.ca.
⁸ EcoSynthetix Inc., 3365 Mainway, Burlington, ON L7M 1A6, Canada. Electronic address: NSmeets@walkerind.com.
⁹ Department of Chemical Engineering, McMaster University, 1280 Main Street, West Hamilton, ON L8S 4L8, Canada. Electronic address: hoaretr@mcmaster.ca.

PMID: 32172832
DOI: 10.1016/j.carbpol.2020.115998

Photopolymerized Starchstarch Nanoparticle (SNP) network hydrogels

Michael J Majcher et al. Carbohydr Polym. 2020.

. 2020 May 15:236:115998.

doi: 10.1016/j.carbpol.2020.115998. Epub 2020 Feb 12.

Authors

Michael J Majcher¹, Carter L McInnis², Sebastian Himbert³, Richard J Alsop⁴, Dennis Kinio⁵, Markus Bleuel⁶, Maikel C Rheinstädter⁷, Niels M B Smeets⁸, Todd Hoare⁹

Affiliations

¹ Department of Chemical Engineering, McMaster University, 1280 Main Street, West Hamilton, ON L8S 4L8, Canada. Electronic address: majcherm@mcmaster.ca.
² Department of Chemical Engineering, McMaster University, 1280 Main Street, West Hamilton, ON L8S 4L8, Canada. Electronic address: carter.l.mcinnis@gmail.com.
³ Department of Physics and Astronomy, McMaster University, 1280 Main Street, West Hamilton, ON L8S 4L8, Canada. Electronic address: himberts@mcmaster.ca.
⁴ Department of Physics and Astronomy, McMaster University, 1280 Main Street, West Hamilton, ON L8S 4L8, Canada. Electronic address: alsoprj@mcmaster.ca.
⁵ EcoSynthetix Inc., 3365 Mainway, Burlington, ON L7M 1A6, Canada. Electronic address: dkinio@ecosynthetix.onmicrosoft.com.
⁶ NIST Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899-6100, United States. Electronic address: markus.bleuel@nist.gov.
⁷ Department of Physics and Astronomy, McMaster University, 1280 Main Street, West Hamilton, ON L8S 4L8, Canada. Electronic address: rheinsm@mcmaster.ca.
⁸ EcoSynthetix Inc., 3365 Mainway, Burlington, ON L7M 1A6, Canada. Electronic address: NSmeets@walkerind.com.
⁹ Department of Chemical Engineering, McMaster University, 1280 Main Street, West Hamilton, ON L8S 4L8, Canada. Electronic address: hoaretr@mcmaster.ca.

PMID: 32172832
DOI: 10.1016/j.carbpol.2020.115998

Abstract

Starch is an attractive biomaterial given its low cost and high protein repellency, but its use in forming functional hydrogels is limited by its high viscosity and crystallinity. Herein, we demonstrate the use of fully amorphous starch nanoparticles (SNPs) as functional hydrogel building blocks that overcome these challenges. Methacrylation of SNPs enables hydrogel formation via photopolymerization, with the low viscosity of SNPs enabling facile preparation of pre-gel suspensions of up to 35 wt% SNPs relative to <10 wt% with linear starch. Small angle neutron scattering indicates a significantly different microstructure in SNP-based hydrogels compared to linear starch-based hydrogels due to the balance between inter- and intra-particle crosslinks, consistent with SNPs forming denser and stiffer hydrogels. Functionalized SNPs are highly cytocompatible at degree of substitution values <0.25 and, once gelled, can effectively repel cell adhesion. The physicochemical versatility and biological functionality of SNP-based hydrogels offer potential in various applications.

Keywords: Biopolymer; Hydrogel; Nanoparticle; Photopolymerization; Starch; Sustainable materials.

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Conflict of interest statement

Declaration of Competing Interest The authors declare no competing financial interest.

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Photopolymerized Starchstarch Nanoparticle (SNP) network hydrogels

Affiliations

Photopolymerized Starchstarch Nanoparticle (SNP) network hydrogels

Authors

Affiliations

Abstract

Conflict of interest statement

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