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Review
. 2019 Dec;33(6):101495.
doi: 10.1016/j.berh.2020.101495. Epub 2020 Mar 12.

The microbiome in spondyloarthritis

Maxime Breban  1 , Marie Beaufrère  2 , Simon Glatigny  3
Affiliations
Review

The microbiome in spondyloarthritis

Maxime Breban et al. Best Pract Res Clin Rheumatol. 2019 Dec.

Abstract

A causal link between the wealth of microbes that populate our body surfaces, designated as microbiota, and inflammatory disorders, including ankylosing spondylitis and the related spondyloarthritis (SpA) has been suspected for decades. This specially concerns the gut microbiota that became only recently accessible to thorough description thanks to massive sequencing methods or metagenomics. Here, we review evidences supporting the existence of microbiota imbalance or dysbiosis in the context of SpA. We also discuss currently existing evidences for a causal relationship between such dysbiosis and disease development, as well as putative therapeutic implications.

Keywords: Animal models; Ankylosing spondylitis; HLA-B27; Microbiota; Reactive arthritis; Spondyloarthritis.

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Conflict of interest statement

Declaration of Competing Interest There are no conflicts of interest pertaining to this work.