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. 2020 Feb 20:25:13.
doi: 10.4103/jrms.JRMS_42_18. eCollection 2020.

Thyroid volume and nodular and diffuse thyroid diseases by ultrasonography in pregnant women: A case-control study

Saeideh Shokri  1 , Ali Hekmatnia  2 , Maryam Farghadani  1 , Ashraf Aminorroaya  3 , Masoud Amini  3 , Maryam Kianpour  3 , Mojtaba Akbari  4 , Farzaneh Hekmatnia  5
Affiliations

Thyroid volume and nodular and diffuse thyroid diseases by ultrasonography in pregnant women: A case-control study

Saeideh Shokri et al. J Res Med Sci. .

Abstract

Background: Currently, it is shown that pregnancy may have an impact on the thyroid that can be leading to pregnancy complications such as abortion, preeclampsia, and preterm delivery. The objective was to compare the thyroid volume, number and characteristics of thyroid nodules, and prevalence of diffuse thyroid diseases in a sample of Iranian pregnant women in the first trimester to nonpregnant women.

Materials and methods: This case-control study was conducted on 298 pregnant and 290 nonpregnant women. Thyroid volume, maximum diameter of thyroid nodules and prevalence of moderate to highly suspicious thyroid nodules, Hashimoto's appearance and goiter were assessed using thyroid ultrasonography. Antithyroperoxidase (TPO) antibodies were measured if the sonographic features were highly suggested for Hashimoto's thyroiditis.

Results: The mean of total thyroid volume in pregnant and nonpregnant women was 6 and 6.5 ml, respectively (P = 0.053), and the median (interquartile range) was 6.2 and 5.5, respectively. Nodules were observed in 16.4% of pregnant and 16.6% of nonpregnant women (P = 0.845). Hashimoto's thyroiditis was detected in 6.7% of pregnant and 12.4% of nonpregnant women (P = 0.013). Anti-TPO antibodies were detected in 5% of pregnant and 9.3% of nonpregnant women (P = 0.034).

Conclusion: The thyroid volume and nodule characteristics in the first trimester of pregnancy were similar to nonpregnant women. Hashimoto's thyroiditis and anti-TPO antibodies in pregnant women were significantly lower than in nonpregnant women.

Keywords: Anti-thyroperoxidase antibody; Hashimoto's disease; pregnancy; thyroid; thyroid diseases; thyroid nodule; thyroid volume; ultrasonography.

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Conflict of interest statement

There are no conflicts of interest.

References

    1. Hansen PS, Brix TH, Bennedbaek FN, Bonnema SJ, Kyvik KO, Hegedüs L. Genetic and environmental causes of individual differences in thyroid size: A study of healthy Danish twins. J Clin Endocrinol Metab. 2004;89:2071–7. - PubMed
    1. Glinoer D, Nayer PD, Bourdoux P, Lemone M, Robyn C, Steirteghem AV, et al. Regulation of maternal thyroid during pregnancy. J Clinic Endocrinol and Metabol. 1990;71:276–87. - PubMed
    1. Stricker R, Echenard M, Eberhart R, Chevailler MC, Perez V, Quinn FA, et al. Evaluation of maternal thyroid function during pregnancy: The importance of using gestational age-specific reference intervals. Eur J Endocrinol. 2007;157:509–14. - PubMed
    1. Fister P, Gaberscek S, Zaletel K, Krhin B, Hojker S, Gersak K. Thyroid function in the third trimester of pregnancy and after delivery in an area of adequate iodine intake. Int J Gynaecol Obstet. 2011;112:52–5. - PubMed
    1. Soldin OP, Tractenberg RE, Hollowell JG, Jonklaas J, Janicic N, Soldin SJ. Trimester-specific changes in maternal thyroid hormone, thyrotropin, and thyroglobulin concentrations during gestation: Trends and associations across trimesters in iodine sufficiency. Thyroid. 2004;14:1084–90. - PMC - PubMed