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. 2020 Feb 20:25:18.
doi: 10.4103/jrms.JRMS_175_18. eCollection 2020.

A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial

Luiz Fernando Rodrigues Junior  1   2 , Fernanda de Souza Nogueira Sardinha Mendes  1 , Vivian Liane Mattos Pinto  1 , Paula Simplicio da Silva  1 , Gilberto Marcelo Sperandio da Silva  1 , Roberta Olmo Pinheiro  3 , Andréa Silvestre de Sousa  1 , Mauro Felippe Felix Mediano  1
Affiliations

A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial

Luiz Fernando Rodrigues Junior et al. J Res Med Sci. .

Abstract

Background: Cardiac rehabilitation exerts anti-inflammatory effect on several cardiovascular diseases; however, these effects were not described for Chagas cardiomyopathy, which is associated with pro-inflammatory imbalance.

Materials and methods: Ten patients with severe Chagas cardiomyopathy performed 8 months of exercise training in a cardiac rehabilitation program. Interleukin-1 beta (IL-1β), IL-8, IL-10, interferon gamma (IF-γ), tumor necrosis factor alpha (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) serum levels were measured using enzyme-linked immunosorbent assay at baseline, 4, and 8 months. The influence of exercise on cytokine levels was evaluated using the one-way analysis of variance for repeated measurements, with Bonferroni posttest for multiple comparisons.

Results: Levels of pro-inflammatory (TNF-α, IL-1β, IL-8, IF-γ, and (MCP-1) and anti-inflammatory (IL-10) cytokines did not vary significantly during the observation period.

Conclusion: Exercise may benefit patients with severe Chagas cardiomyopathy by curbing the production of pro-inflammatory cytokines in this disease characterized by a continuous state of inflammation.

Keywords: Cardiac rehabilitation; Chagas cardiomyopathy; cytokines; heart failure.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Individual cytokine changes during the follow-up. The levels of (a) interleukin 1β, (b) interleukin-8, (c) interleukin-10, (d) monocyte chemoattractant protein-1, (e) interferon-γ, and (f) tumor necrosis factor-α of each volunteer are presented for baseline, 4 and 8 months of follow-up. IL1-β = Interleukin 1β; IL-8 = Interleukin 8; IL-10 = Interleukin 10; MCP-1 = Monocytes chemoattractant protein-1; TNF-α = Tumor necrosis factor α
See this image and copyright information in PMC

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