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. 2020 Jun;63(6):484-489.
doi: 10.1002/ajim.23106. Epub 2020 Mar 16.

Malignant mesothelioma following repeated exposures to cosmetic talc: A case series of 75 patients

Theresa S Emory  1 , John C Maddox  1 , Richard L Kradin  2   3
Affiliations

Malignant mesothelioma following repeated exposures to cosmetic talc: A case series of 75 patients

Theresa S Emory et al. Am J Ind Med. 2020 Jun.

Abstract

Background: Asbestos is the primary known cause of malignant mesothelioma. Some cosmetic talc products have been shown to contain asbestos. Recently, repeated exposures to cosmetic talc have been implicated as a cause of mesothelioma.

Methods: Seventy-five individuals (64 females; 11 males) with malignant mesothelioma, whose only known exposure to asbestos was repeated exposures to cosmetic talcum powders, were reviewed in medical-legal consultation. Out of the 75 cases, 11 were examined for asbestiform fibers.

Results: All subjects had pathologically confirmed malignant mesothelioma. The mean age at diagnosis was 61 ± 17 years. The mean latency from exposure to diagnosis was 50 ± 13 years. The mean exposure duration was 33 ± 16 years. Four mesotheliomas (5%) occurred in individuals working as barbers/cosmetologists, or in a family member who swept the barber shop. Twelve (16%) occurred in individuals less than 45 years old (10 females; 2 males). Forty-eight mesotheliomas were pleural (40 females; 8 males), 23 were peritoneal (21 females; 2 males). Two presented with concomitant pleural and peritoneal disease. There was one pericardial, and one testicular mesothelioma. The majority (51) were of the epithelioid histological subtype, followed by 13 biphasic, 8 sarcomatoid, 2 lymphohistiocytoid, and 1 poorly differentiated. Of the 11 individuals whose nontumorous tissues were analyzed for the presence of asbestiform fibers, all showed the presence of anthophyllite and/or tremolite asbestos.

Conclusions: Mesotheliomas can develop following exposures to cosmetic talcum powders. These appear to be attributable to the presence of anthophyllite and tremolite contaminants in cosmetic talcum powder.

Keywords: anthophyllite; females; mesothelioma; peritoneal; pleural; talc; tremolite.

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Conflict of interest statement

Drs Emory, Maddox, and Kradin have testified in asbestos litigation, primarily for plaintiffs.

Comment in

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