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Review
. 2020;26(21):2475-2491.
doi: 10.2174/1381612826666200316145725.

The Influence of Vitamin D on Neurodegeneration and Neurological Disorders: A Rationale for its Physio-pathological Actions

Maria Morello  1 , Massimo Pieri  1 , Rossella Zenobi  1 , Alessandra Talamo  2 , Delphine Stephan  3 , Verena Landel  3 , François Féron  3 , Pascal Millet  3   4   5
Affiliations
Review

The Influence of Vitamin D on Neurodegeneration and Neurological Disorders: A Rationale for its Physio-pathological Actions

Maria Morello et al. Curr Pharm Des. 2020.

Abstract

Vitamin D is a steroid hormone implicated in the regulation of neuronal integrity and many brain functions. Its influence, as a nutrient and a hormone, on the physiopathology of the most common neurodegenerative diseases is continuously emphasized by new studies. This review addresses what is currently known about the action of vitamin D on the nervous system and neurodegenerative diseases such as Multiple Sclerosis, Alzheimer's disease, Parkinson's disease and Amyotrophic Lateral Sclerosis. Further vitamin D research is necessary to understand how the action of this "neuroactive" steroid can help to optimize the prevention and treatment of several neurological diseases.

Keywords: Alzheimer's disease; Parkinson's disease; Vitamin D; amyotrophic lateral sclerosis; multiple sclerosis; neurodegenerative diseases..

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