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Meta-Analysis
. 2020 Mar;99(11):e19388.
doi: 10.1097/MD.0000000000019388.

Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: A meta-analysis

Zehan Chen  1 , Chang Wang  1 , Di You  2 , Shishun Zhao  1 , Zhe Zhu  3 , Meng Xu  4
Affiliations
Meta-Analysis

Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: A meta-analysis

Zehan Chen et al. Medicine (Baltimore). 2020 Mar.

Abstract

Background: This meta-analysis focuses on the controversial efficacy and safety of platelet-rich plasma (PRP) as compared with hyaluronic acid (HA) in the clinical treatment of knee osteoarthritis. We have attempted to provide an evidence-based medicine protocol for the conservative treatment of knee osteoarthritis. In addition, we included the latest relevant literature in this meta-analysis, and a staging study was conducted to compare the therapeutic effects of PRP and HA for knee osteoarthritis over different time periods.

Methods: An online computer search with "platelet-rich plasma" and "knee osteoarthritis" as search terms was conducted in the PubMed, EMBASE, and Cochrane Library databases. We conducted a quality assessment of the retrieved literature and extracted the following indicators: visual analog scale (VAS) score, subjective International Knee Documentation Committee (IKDC) score, Western Ontario and McMaster Universities (WOMAC) score, Knee Injury and Osteoarthritis Outcome Score (KOOS), and adverse events. RevMan5.3 software was used to determine the effect sizes, and indicators were compared across studies at three different time points from the administration of treatment.

Results: A total of 14 randomized controlled trials (RCTs) involving 1350 patients were included. Long-term VAS, IKDC, WOMAC-Pain, WOMAC-Stiffness, WOMAC-Physical Function, and WOMAC-Total scores at each time point were higher in the PRP group than in the HA group. There were no significant differences in the remaining indicators between the two groups.

Conclusion: Compared with HA, PRP offers obvious advantages in the conservative treatment of knee osteoarthritis. Treatment with PRP can reduce long-term pain and improve knee joint function with no additional risks. Therefore, PRP can be widely used for the conservative treatment of knee osteoarthritis.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flowchart of study selection.
Figure 2
Figure 2
Methodological quality of the included studies.
Figure 3
Figure 3
The methodological quality of the included studies.
See this image and copyright information in PMC

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