Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May;35(5):1057-1061.
doi: 10.1111/jocs.14505. Epub 2020 Mar 16.

The relationship between neurocognitive decline and the heart-lung machine

Christina L Tamargo  1 , Mousa Botros  1 , Radu V Saveanu  1
Affiliations

The relationship between neurocognitive decline and the heart-lung machine

Christina L Tamargo et al. J Card Surg. 2020 May.

Abstract

Surgery involving the use of cardiopulmonary bypass (CPB) has long been associated with cerebral changes and may also contribute to adverse neurocognitive outcomes. However, there is a debate as to whether bypass itself is responsible for these changes. We conducted a systematic literature review on PubMed, supplementing our work with recent articles from other sources to examine the current evidence on neurocognitive decline associated with CPB. While surgeries involving CPB appear to be associated with cerebral changes and potentially with neurocognitive decline, it is unclear as to whether decline is related to the procedure itself. It is possible that the impacts of CPB can be more readily observed among individuals with preoperative cognitive impairment. It is thus important to screen for subtle and more apparent preoperative cognitive impairment as a risk factor for adverse outcomes. Further research, comparing on-pump and off-pump cohorts and involving intensive screening of preoperative cognitive decline, is indicated to elucidate the true neurocognitive consequences of the heart-lung machine.

Keywords: cardiopulmonary bypass; dementia; heart-lung machine; mild neurocognitive impairment; neurocognitive decline.

PubMed Disclaimer

References

REFERENCES

    1. Selnes OA, McKhann GM. Neurocognitive complications after coronary artery bypass surgery. Ann Neurol. 2005;57(5):615-621.
    1. Selnes OA, Goldsborough MA, Borowicz LM, McKhann GM. Neurobehavioural sequelae of cardiopulmonary bypass. Lancet. 1999;353(9164):1601-1606.
    1. Mullges W, Franke D, Reents W, Babin-Ebell J. Brain microembolic counts during extracorporeal circulation depend on aortic cannula position. Ultrasound Med Biol. 2001;27(7):933-936.
    1. Nedelmann M, Schleicher N, Doenges S, et al. Ultrasound destruction of air microemboli as a novel approach to brain protection in cardiac surgery. J Cardiothorac Vasc Anesth. 2013;27(5):876-883.
    1. Mao Z, Zhong X, Yin J, Zhao Z, Hu X, Hackett ML. Predictors associated with stroke after coronary artery bypass grafting: a systematic review. J Neurol Sci. 2015;357(1-2):1-7.

Publication types

LinkOut - more resources