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. 2020 Mar 16;15(3):e0230137.
doi: 10.1371/journal.pone.0230137. eCollection 2020.

Intrauterine exposure to perfluorinated compounds and overweight at age 4: A case-control study

Matilda Martinsson  1 , Christel Nielsen  1 , Jonas Björk  1 , Lars Rylander  1 , Ebba Malmqvist  1 , Christian Lindh  1 , Anna Rignell-Hydbom  1
Affiliations

Intrauterine exposure to perfluorinated compounds and overweight at age 4: A case-control study

Matilda Martinsson et al. PLoS One. .

Abstract

Aims: The aims were to investigate the association between maternal serum levels of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS) and perfluorononanoic acid (PFNA) in early pregnancy and overweight in the child at 4 years and to assess potential heterogeneity in exposure effect between strata with different levels of other risk factors for overweight.

Methods: We used a case-control design and included 354 cases (ISO-BMI ≥ 18 kg/m2) and 2 controls per case (ISO-BMI ≤17 kg/m2) from child health care centers in Malmö, Sweden. Controls were selected stratified on risk scores for overweight in a propensity score framework. Maternal serum levels were analyzed in biobanked samples collected by routine around gestational week 14. Logistic regression was used to estimate odds ratios between quartiles of maternal serum levels and child overweight at age 4.

Results: There were no consistent monotonic exposure-response relationships. We found some significant odds ratios in specific quartiles but these were regarded as spurious findings. The absence of an effect was consistent over risk strata.

Conclusions: We did not find evidence of an association between maternal serum levels of PFOS, PFOA, PFHxS and PFNA in early pregnancy and child overweight at age 4. The level of other risk factors for overweight did not affect children's susceptibility to prenatal PFAS exposure.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flowchart describing the inclusion of the study population.
See this image and copyright information in PMC

References

    1. Vestergren R, Cousins IT, Trudel D, Wormuth M, Scheringer M. Estimating the contribution of precursor compounds in consumer exposure to PFOS and PFOA. Chemosphere. 2008;73(10):1617–24. Epub 2008/10/07. 10.1016/j.chemosphere.2008.08.011 . - DOI - PubMed
    1. Li Y, Fletcher T, Mucs D, Scott K, Lindh CH, Tallving P, et al. Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water. Occup Environ Med. 2018;75(1):46–51. Epub 2017/11/15. 10.1136/oemed-2017-104651 - DOI - PMC - PubMed
    1. Zhang Y, Beesoon S, Zhu L, Martin JW. Biomonitoring of perfluoroalkyl acids in human urine and estimates of biological half-life. Environ Sci Technol. 2013;47(18):10619–27. Epub 2013/08/29. 10.1021/es401905e . - DOI - PubMed
    1. Lee YJ, Kim MK, Bae J, Yang JH. Concentrations of perfluoroalkyl compounds in maternal and umbilical cord sera and birth outcomes in Korea. Chemosphere. 2013;90(5):1603–9. Epub 2012/09/20. 10.1016/j.chemosphere.2012.08.035 . - DOI - PubMed
    1. Gützkow KB, Haug LS, Thomsen C, Sabaredzovic A, Becher G, Brunborg G. Placental transfer of perfluorinated compounds is selective—A Norwegian Mother and Child sub-cohort study. Int J Hyg Environ Health. 2012;215(2):216–9. Epub 2011/09/23. 10.1016/j.ijheh.2011.08.011 . - DOI - PubMed

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