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Observational Study
. 2020 Mar 16;19(1):34.
doi: 10.1186/s12933-020-01008-5.

Triglyceride glucose index is an independent predictor for the progression of coronary artery calcification in the absence of heavy coronary artery calcification at baseline

Ki-Bum Won  1   2 , Eun Ji Park  3 , Donghee Han  2   4 , Ji Hyun Lee  5 , Su-Yeon Choi  6 , Eun Ju Chun  7 , Sung Hak Park  8 , Hae-Won Han  9 , Jidong Sung  10 , Hae Ok Jung  11 , Hyuk-Jae Chang  12   13
Affiliations
Observational Study

Triglyceride glucose index is an independent predictor for the progression of coronary artery calcification in the absence of heavy coronary artery calcification at baseline

Ki-Bum Won et al. Cardiovasc Diabetol. .

Abstract

Background: Data on the relationship between the triglyceride glucose (TyG) index and coronary artery calcification (CAC) progression is limited. This longitudinal study evaluated the association of TyG index with CAC progression in asymptomatic adults.

Methods: We enrolled 12,326 asymptomatic Korean adults who had at least two CAC evaluations. The TyG index was determined using ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up coronary artery calcium score (CACS) (Δ√transformed CACS). Annualized Δ√transformed CACS was defined as Δ√transformed CACS divided by the inter-scan period.

Results: During a mean 3.3 years, the overall incidence of CAC progression was 30.6%. The incidence of CAC progression (group I [lowest]: 22.7% versus [vs.] group II: 31.7% vs. group III [highest]: 37.5%, P < 0.001) and annualized Δ√transformed CACS (group I: 0.46 ± 1.44 vs. group II: 0.71 ± 2.02 vs. group III: 0.87 ± 1.75, P < 0.001) were markedly elevated with increasing TyG index tertiles. Multivariate linear regression analysis showed that TyG index was associated with annualized Δ√transformed CACS (β = 0.066, P = 0.036). In multivariate logistic regression analysis, the TyG index was significantly associated with CAC progression in baseline CACS ≤ 100.

Conclusion: The TyG index is an independent predictor of CAC progression, especially in adults without heavy baseline CAC.

Keywords: Atherosclerosis; Coronary artery calcification; Insulin resistance; Triglyceride glucose index.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Comparison of baseline coronary artery calcification according to triglyceride glucose index tertiles. CACS coronary artery calcium scores
Fig. 2
Fig. 2
Changes of CAC according to TyG index tertiles. CAC coronary artery calcification, TyG triglyceride glucose
Fig. 3
Fig. 3
Changes of CAC according to the baseline CACS. CAC coronary artery calcification, CACS coronary artery calcium score
See this image and copyright information in PMC

References

    1. Roth GA, Forouzanfar MH, Moran AE, Barber R, Nguyen G, Feigin VL, Naghavi M, Mensah GA, Murray CJ. Demographic and epidemiologic drivers of global cardiovascular mortality. N Engl J Med. 2015;372(14):1333–1341. doi: 10.1056/NEJMoa1406656. - DOI - PMC - PubMed
    1. Wong ND, Hsu JC, Detrano RC, Diamond G, Eisenberg H, Gardin JM. Coronary artery calcium evaluation by electron beam computed tomography and its relation to new cardiovascular events. Am J Cardiol. 2000;86(5):495–498. doi: 10.1016/S0002-9149(00)01000-6. - DOI - PubMed
    1. Budoff MJ, Shaw LJ, Liu ST, Weinstein SR, Mosler TP, Tseng PH, Flores FR, Callister TQ, Raggi P, Berman DS. Long-term prognosis associated with coronary calcification: observations from a registry of 25,253 patients. J Am Coll Cardiol. 2007;49(18):1860–1870. doi: 10.1016/j.jacc.2006.10.079. - DOI - PubMed
    1. Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, Liu K, Shea S, Szklo M, Bluemke DA, O’Leary DH, Tracy R, Watson K, Wong ND, Kronmal RA. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med. 2008;358(13):1336–1345. doi: 10.1056/NEJMoa072100. - DOI - PubMed
    1. Budoff MJ, Hokanson JE, Nasir K, Shaw LJ, Kinney GL, Chow D, Demoss D, Nuguri V, Nabavi V, Ratakonda R, Berman DS, Raggi P. Progression of coronary artery calcium predicts all-cause mortality. JACC Cardiovasc Imaging. 2010;3(12):1229–1236. doi: 10.1016/j.jcmg.2010.08.018. - DOI - PubMed

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