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. 2020 Mar 16;19(1):42.
doi: 10.1186/s12944-020-01204-y.

Dyslipidemia and cardiovascular disease risk among the MASHAD study population

Mahshad Hedayatnia  1 , Zahra Asadi  1   2 , Reza Zare-Feyzabadi  3 , Mahdiyeh Yaghooti-Khorasani  3 , Hamideh Ghazizadeh  2   3   4 , Roshanak Ghaffarian-Zirak  3 , Abolfazl Nosrati-Tirkani  3 , Maryam Mohammadi-Bajgiran  3 , Mohadese Rohban  3 , Fatemeh Sadabadi  3 , Hamid-Reza Rahimi  3 , Marzieh Ghalandari  3 , Mohammad-Seddigh Ghaffari  5 , Asa Yousefi  5 , Elnaz Pouresmaeili  5 , Mohammad-Reza Besharatlou  5 , Mohsen Moohebati  6 , Gordon A Ferns  7 , Habibollah Esmaily  8 , Majid Ghayour-Mobarhan  9   10
Affiliations

Dyslipidemia and cardiovascular disease risk among the MASHAD study population

Mahshad Hedayatnia et al. Lipids Health Dis. .

Abstract

Introduction: Dyslipidemia may be defined as increased levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), or a decreased serum high-density lipoprotein cholesterol (HDL-C) concentration. Dyslipidemia is an established risk factor for cardiovascular disease (CVD). We aimed to investigate the association of dyslipidemia and CVD events among a population sample from Mashhad, in northeastern Iran.

Material and methods: This prospective cohort study comprised a population of 8698 men and women aged 35-65 years who were recruited from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study. Socioeconomic and demographic status, anthropometric parameters, laboratory evaluations, lifestyle factors, and medical history were gathered through a comprehensive questionnaire and laboratory and clinical assessment for all participants. Cox regression model and 95% confidence interval (CI) were used to evaluate the association of dyslipidemia and its components with CVD incidence.

Results: After 6 years of follow-up, 233 cases of CVD (including 119 cases of unstable angina [US], 74 cases of stable angina [SA], and 40 cases of myocardial infarction [MI]) were identified in the study population. Unadjusted baseline serum LDL-C, TC, and TG levels were positively associated with the risk of total CVD events among the entire population (HR: 1.54, 95% CI: 1.19-2; P-value< 0.01; HR: 1.53; 95% CI: 1.18-1.98; P < 0.01; HR: 1.57; 95% CI: 1.27-2.03; P < 0.01, respectively). However, after adjusting for confounding factors (age, body mass index [BMI], family history of CVD, smoking status [non-smoker, ex-smoker and current smoker], lipid lowering drug treatment, anti-hypertensive drug treatment, hypertension, healthy eating index [HEI], total energy intake, and presence of diabetes mellitus), a significant direct association only remained between TC and MI risk in men (HR: 2.71; 95%CI: 1.12-6.57; P-value< 0.05).

Conclusion: In the present study, TC baseline level was significantly associated with the risk of MI among men.

Keywords: Cardiovascular disease; Dyslipidemia; Myocardial infarction; Stable angina; Total cholesterol; Unstable angina.

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Conflict of interest statement

The authors declare that they have no competing interests.

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