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. 2020 Mar 16;18(1):72.
doi: 10.1186/s12955-020-01319-x.

Health-related quality of life and associated factors among cervical cancer patients at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia

Liya Teklu Araya  1 , Teferi Gedif Fenta  1 , Beate Sander  2   3   4   5 , Girma Tekle Gebremariam  6 , Gebremedhin Beedemariam Gebretekle  7
Affiliations

Health-related quality of life and associated factors among cervical cancer patients at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia

Liya Teklu Araya et al. Health Qual Life Outcomes. .

Abstract

Background: Cancer of the cervix is the most frequent cancer among women in Ethiopia. The disease burden and its treatment adversely affects patients' health-related quality of life (HRQoL). We aimed to investigate the HRQoL and its predictors among cervical cancer patients in Ethiopia.

Methods: A hospital-based cross-sectional study was conducted from January to June 2018 at the oncology unit of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia. A total of 404 cervical cancer patients were interviewed using validated Amharic version of the European Organization for Research and Treatment of Cancer module (EORTC QLQ-C30), cervical cancer module (EORTC QLQ-CX24), and Euro Quality of Life Group's 5-Domain Questionnaires 5-Levels (EQ-5D) questionnaires. ANOVA test was used to determine the effect of patients' characteristics on mean scores of the different domains of HRQoL and stepwise multivariable logistic regression was performed to identify predictors of HRQoL. Coefficients of level-specific utility values obtained from a hybrid regression model for the Ethiopian general population were used to compute utility.

Results: The mean age of patients was 52.1 ± 10.4 years and 379 (93.8%) of the patients were receiving service at the outpatient clinic. About one-third (35%) of patients were diagnosed with stage IV cervical cancer. Mean global health status/QoL, mean utility and visual analog scale scores were 48.3 ± 23.77, 0.77 and 65.7 ± 20.83, respectively. Physical functioning (AOR = 4.98, 95% CI:2.16-11.49), emotional functioning (AOR = 5.25, 95% CI:2.26-12.17), pain (AOR = 5.79, 95% CI:2.30-14.57), and symptom experience (AOR = 4.58, 95% CI:1.95-10.79) were associated with patients' HRQoL.

Conclusions: Cervical cancer significantly affects patient's HRQoL and hence, efforts to improve HRQoL should be commenced especially in terms of physical and emotional functioning, pain, and symptom experience.

Keywords: Cervical cancer; EQ-5D; Ethiopia; Health-related quality of life; Utility.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Descriptive results of EQ-5D dimensions among cervical cancer patients
See this image and copyright information in PMC

References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. doi: 10.3322/caac.21492. - DOI - PubMed
    1. World Health Organization (WHO) WHO leads the way towards the elimination of cervical cancer as a public health concern. Geneva: WHO; 2019.
    1. Bruni L, Albero G, Serrano B, Mena M, Gómez D, Muñoz J, Bosch FX, de Sanjosé S. ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in the World. Summary Report 17 June 2019. availabe at: https://hpvcentre.net/statistics/reports/XFX.pdf. Accessed on August 12, 2019.
    1. Hailemariam T, Yohannes B, Aschenaki H, Mamaye E, Orkaido G, Seta M. Prevalence of cervical Cancer and associated risk factors among women attending cervical Cancer screening and diagnosis Center at Yirgalem General Hospital, Southern Ethiopia. J Cancer Sci Ther. 2017;9(11):730–735. doi: 10.4172/1948-5956.1000500. - DOI
    1. Federal Ministry of Health E. National Cancer Control and Implementation Plan. 2019;Availablefrom: https://www.iccpportal.org/sites/default/files/plans/NCCP%25Ethiopia%25f.... Accessed on August 12, 2019.

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