Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb;29(1):158-165.
doi: 10.1007/s12350-020-02092-6. Epub 2020 Mar 16.

[18F]FDG-PET CT for the evaluation of native valve endocarditis

Gad Abikhzer  1 , Patrick Martineau  2   3 , Jean Grégoire  4 , Vincent Finnerty  4 , Francois Harel  4 , Matthieu Pelletier-Galarneau  5   6
Affiliations

[18F]FDG-PET CT for the evaluation of native valve endocarditis

Gad Abikhzer et al. J Nucl Cardiol. 2022 Feb.

Abstract

Background: We examined the use of [18F]FDG-PET/CT for the diagnosis of native valve endocarditis (NVE).

Methods: PET/CT images in patients with suspected NVE were retrospectively reviewed independently by two experienced physicians blinded to all clinical information. The gold standard consisted of surgical findings, when available, or the modified Duke criteria.

Results: Fifty four subjects were included, 31 (57%) with a diagnosis of NVE. [18F]FDG-PET/CT correctly identified 21/31 (67.7%) subjects, yielding a sensitivity and specificity of 68% (95% CI 49-83%) and 100% (95% CI 85-100%), respectively. The sensitivity and specificity of the modified Duke criteria were 48% and 74%, respectively. Positive and negative predictive values of PET were 100% (95% CI 84-100%) and 70% (95% CI 51-84%), respectively. Modifying the Duke criteria to include [18F]FDG-PET positivity as a major criterion increased sensitivity to 77% without affecting specificity and led to the correct reclassification of 8/18 (44.4%) subjects from Possible IE to Definite IE.

Conclusion: The addition of a positive [18F]FDG-PET/CT as a major criterion in the modified Duke Criteria improved performance of the criteria for the diagnosis of NVE, particularly in those subjects with Possible IE.

Keywords: FDG; Infective endocarditis; Native valve; Positron emission tomography; fluorodeoxyglucose.

PubMed Disclaimer

Comment in

References

    1. Pant S, Patel NJ, Deshmukh A, et al. Trends in infective endocarditis incidence, microbiology, and valve replacement in the United States from 2000 to 2011. J Am Coll Cardiol. 2015;65:2070–6. https://doi.org/10.1016/j.jacc.2015.03.518 . - DOI - PubMed
    1. Toyoda N, Chikwe J, Itagaki S, et al. Trends in infective endocarditis in California and New York state, 1998–2013. JAMA. 2017;317:1652–60. https://doi.org/10.1001/jama.2017.4287 . - DOI - PubMed - PMC
    1. Hoen B, Duval X. Clinical practice. Infective endocarditis. N Engl J Med. 2013;368:1425–33. https://doi.org/10.1056/NEJMcp1206782 . - DOI - PubMed
    1. Raoult D, Casalta JP, Richet H, et al. Contribution of systematic serological testing in diagnosis of infective endocarditis. J Clin Microbiol. 2005;43:5238–42. https://doi.org/10.1128/JCM.43.10.5238-5242.2005 . - DOI - PubMed - PMC
    1. Murdoch DR, Corey GR, Hoen B, et al. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: The International Collaboration on Endocarditis-Prospective Cohort Study. Arch Intern Med. 2009;169:463–73. https://doi.org/10.1001/archinternmed.2008.603 . - DOI - PubMed - PMC

MeSH terms

Substances

LinkOut - more resources