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Comment
. 2020 Jun;95(6):E144-E146.
doi: 10.1002/ajh.25787. Epub 2020 Apr 7.

Lower white matter volume in beta-thalassemia associated with anemia and cognitive performance

Soyoung Choi  1   2   3 , Richard M Leahy  1   2 , John C Wood  3   4
Affiliations
Comment

Lower white matter volume in beta-thalassemia associated with anemia and cognitive performance

Soyoung Choi et al. Am J Hematol. 2020 Jun.
No abstract available

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Figures

FIGURE 1
FIGURE 1
3D renderings of significant voxels superimposed on the brain surface atlas template in the left and right hemispheres. A, Group comparisons between beta-thalassemia patients and controls where positive t-values (red) indicated higher DI in beta-thalassemia patients than controls and negative t-values (blue) indicate lower DI in beta-thalassemia patients than controls. B, Correlation between Deformation Index and hemoglobin where positive correlation coefficient (r) in red indicates lower white matter DI with anemia and negative correlation (blue) indicate higher DI with anemia as indicated by the colorbar. Only voxels with corrected P-value ≤ .05 are shown. Results were not thresholded by cluster size
FIGURE 2
FIGURE 2
Group comparisons performed using voxel-wise t-tests. Significant voxels (P ≤ .05) were retained after family-wise error rate correction using Gaussian random field theory (α = .05)
See this image and copyright information in PMC

Comment on

References

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    1. Russo AG, Ponticorvo S, Tartaglione I, et al. No increased cerebrovascular involvement in adultbeta-thalassemia by advanced MRI analyses. Blood Cells Mol Dis. 2019;78:9–13. 10.1016/j.bcmd.2019.05.001. - DOI - PubMed
    1. Manara R, Canna A, Caiazza M, et al. White matter volume changes in adult beta-thalassemia: negligible and unrelated to anemia and cognitive performances. Am J Hematol. 2020;95(6):E142–E144. 10.1002/ajh.25790. - DOI - PubMed