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Review
. 2020 Feb 26:15:1-5.
doi: 10.15420/ecr.2019.05. eCollection 2020 Feb.

Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype?

Alexandros Protonotarios  1   2 , Perry M Elliott  1   2
Affiliations
Review

Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype?

Alexandros Protonotarios et al. Eur Cardiol. .

Abstract

Arrhythmogenic cardiomyopathy (AC) is a clinical entity that has evolved conceptually over the past 30 years. Advances in cardiac imaging and the introduction of genetics into everyday practice have revealed that AC comprises multiple phenotypes that are dependent on genetic or acquired factors. In this study, the authors summarise the approach to the identification of the AC phenotype and its underlying causes. They believe that AC represents a paradigm for personalised medicine in cardiology and that better stratification of the disease will enhance the development of mechanism-based treatments.

Keywords: Arrhythmogenic cardiomyopathy; disease; genetics; phenotype; treatment.

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Conflict of interest statement

Disclosure: The authors have no conflicts of interest to declare.

Figures

Figure 1:
Figure 1:. The Type of Ventricular Involvement in Genetic Subgroups with Arrhythmogenic Cardiomyopathy
Figure 2:
Figure 2:. Clinical Presentations and Differential Diagnoses
Figure 3:
Figure 3:. Algorithmic Representation of the Evaluation and Management of Arrhythmogenic Cardiomyopathy
See this image and copyright information in PMC

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