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Case Reports
. 2020 Jul;20(7):1859-1863.
doi: 10.1111/ajt.15869. Epub 2020 Mar 31.

Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression

Lan Zhu  1   2 , Xizhen Xu  3 , Ke Ma  4 , Junling Yang  5 , Hanxiong Guan  6 , Song Chen  1   2 , Zhishui Chen  1   2 , Gang Chen  1   2
Affiliations
Case Reports

Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression

Lan Zhu et al. Am J Transplant. 2020 Jul.

Abstract

The current outbreak of Coronavirus Disease 2019 (COVID-19) has raised great concern worldwide, but its impact on transplant recipients is unknown. We report here the clinical features and therapeutic course of the first reported renal transplant recipient with confirmed COVID-19 pneumonia. This is a 52-year-old man who received kidney transplantation 12 years ago. His overall clinical characteristics (symptoms, laboratory examinations, and chest CT) were similar to those of non-transplanted COVID-19 patients. Following a treatment regimen consisting of reduced immunosuppressant use and low dose methylprednisolone-based therapy, the COVID-19 pneumonia in this long-term immunosuppressive patient was successfully recovered. This effectively treated case has reference value for the future treatment of other transplant patients with COVID-19 pneumonia.

Keywords: COVID-19; coronavirus; immunosuppression; pneumonia; renal transplantation.

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Figures

FIGURE 1
FIGURE 1
Symptoms and treatments including immunosuppressive adjustment according to day of illness and day of hospitalization
FIGURE 2
FIGURE 2
High-resolution computed tomography images before and after treatment. A, Multiple ground glass density lesions were observed in the upper and lower lobe of the lung, some with consolidation, although without obvious subpleural distribution. B, The lesion range enlarged, and new lesions were observed. C, The lesion was almost completely absorbed, leaving only a few blurs [Color figure can be viewed at wileyonlinelibrary.com]
See this image and copyright information in PMC

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References

    1. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. - PMC - PubMed
    1. Rothe C, Schunk M, Sothmann P, et al. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N Engl J Med. 2020;382(10):970–971. - PMC - PubMed
    1. Holshue ML, DeBolt C, Lindquist S, et al. First case of 2019 novel coronavirus in the United States. N Engl J Med. 2020;382(10):929–936. - PMC - PubMed
    1. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA. [published online ahead of print 2020]. 10.1001/jama.2020.2648. - DOI - PubMed
    1. Michaels MG, La Hoz RM, Danziger-Isakov L, et al. Coronavirus disease 2019: implications of emerging infections for transplantation. Am J Transplant. [published online ahead of print 2020]. 10.1111/ajt.15832. - DOI - PMC - PubMed

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