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Comparative Study
. 2020 Apr 16;382(16):1564-1567.
doi: 10.1056/NEJMc2004973. Epub 2020 Mar 17.

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1

Neeltje van Doremalen  1 , Trenton Bushmaker  1 , Dylan H Morris  2 , Myndi G Holbrook  1 , Amandine Gamble  3 , Brandi N Williamson  1 , Azaibi Tamin  4 , Jennifer L Harcourt  4 , Natalie J Thornburg  4 , Susan I Gerber  4 , James O Lloyd-Smith  5 , Emmie de Wit  6 , Vincent J Munster  6
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Comparative Study

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1

Neeltje van Doremalen et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Viability of SARS-CoV-1 and SARS-CoV-2 in Aerosols and on Various Surfaces.
As shown in Panel A, the titer of aerosolized viable virus is expressed in 50% tissue-culture infectious dose (TCID50) per liter of air. Viruses were applied to copper, cardboard, stainless steel, and plastic maintained at 21 to 23°C and 40% relative humidity over 7 days. The titer of viable virus is expressed as TCID50 per milliliter of collection medium. All samples were quantified by end-point titration on Vero E6 cells. Plots show the means and standard errors ( bars) across three replicates. As shown in Panel B, regression plots indicate the predicted decay of virus titer over time; the titer is plotted on a logarithmic scale. Points show measured titers and are slightly jittered (i.e., their horizontal positions are modified by a small random amount to reduce overlap) along the time axis to avoid overplotting. Lines are random draws from the joint posterior distribution of the exponential decay rate (negative of the slope) and intercept (initial virus titer) to show the range of possible decay patterns for each experimental condition. There were 150 lines per panel, including 50 lines from each plotted replicate. As shown in Panel C, violin plots indicate posterior distribution for the half-life of viable virus based on the estimated exponential decay rates of the virus titer. The dots indicate the posterior median estimates, and the black lines indicate a 95% credible interval. Experimental conditions are ordered according to the posterior median half-life of SARS-CoV-2. The dashed lines indicate the limit of detection, which was 3.33×100.5 TCID50 per liter of air for aerosols, 100.5 TCID50 per milliliter of medium for plastic, steel, and cardboard, and 101.5 TCID50 per milliliter of medium for copper.
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