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Review
. 2020 Mar 8;21(5):1851.
doi: 10.3390/ijms21051851.

The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy

Kijeong Lee  1 , Sang Hag Lee  1 , Tae Hoon Kim  1
Affiliations
Review

The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy

Kijeong Lee et al. Int J Mol Sci. .

Abstract

Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD2, PGI2, PGE2, PGF2, and thromboxane B2. PGs signal through G-protein coupled receptors, and individual PGs affect allergic inflammation through different mechanisms according to the receptors with which they are associated. In this review article, we have focused on the metabolism of the cyclooxygenase pathway, and the distinct biological effect of each PG type on various cell types involved in allergic airway diseases, including asthma, allergic rhinitis, nasal polyposis, and aspirin-exacerbated respiratory disease.

Keywords: AERD; PGD2; PGE2; allergic rhinitis; allergy; asthma; prostaglandins.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Prostaglandin biosynthesis pathways and pharmacologic agents used in clinical trials for human respiratory allergic diseases.
Figure 2
Figure 2
Stimulatory and inhibitory effects of prostaglandins, and their receptors, in different cell types involved in the pathophysiology of respiratory allergies.
Figure 3
Figure 3
The role of prostaglandins and their receptors in dendritic cell–T cell interaction and Th2 differentiation.
Figure 4
Figure 4
The role of prostaglandins and their receptors in type 2 innate lymphoid cells.
Figure 5
Figure 5
The role of prostaglandins and their receptors in eosinophil function, including bone marrow trafficking, migration, and degranulation.
See this image and copyright information in PMC

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