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Randomized Controlled Trial
. 2020 Mar 18;20(1):77.
doi: 10.1186/s12903-020-1063-3.

Randomized controlled trial on the effectiveness of absorbable collagen sponge after extraction of impacted mandibular third molar: split-mouth design

Jin-Woo Kim  1 , Tae-Whan Seong  1 , Sura Cho  1 , Sun-Jong Kim  2
Affiliations
Randomized Controlled Trial

Randomized controlled trial on the effectiveness of absorbable collagen sponge after extraction of impacted mandibular third molar: split-mouth design

Jin-Woo Kim et al. BMC Oral Health. .

Abstract

Background: The purpose of this study was to compare the effectiveness of absorbable collagen sponge insertion in tooth extraction sites for socket healing of the impacted mandibular third molar.

Methods: Thirty-six patients with bilateral mandibular impacted third molars based on Pell-Gregory and Winter classification were included in this study. This study was a randomized clinical trial utilizing a split-mouth design with one side assigned as collagen sponge insertion and the other side assigned as the control. Post-operative clinical complications, periodontal integrities, and radiographic outcomes were assessed at 1, 2, and 14-weeks post operatively.

Results: Five patients were excluded during the follow-up period due to loss of follow-up. The study was conducted on 31 patients in total. The mean VAS score of collagen sponge insertion side at 1 week post operation was 1.42 ± 1.26, which was significantly lower than the control side (P < 0.05). The mean probing depth of collagen sponge insertion side at 2-week post operation was 5.55 ± 2.28 mm, which was significantly lower than the control side (7.13 ± 1.86; P < 0.05). Other various measurements including radiographic outcomes showed no significant group differences.

Conclusions: Placement of collagen sponge after extraction of mandibular impacted third molar reduced early stage post-operative complications and enhanced initial healing of soft tissues and periodontal defects.

Trial registration: This study was retrospectively registered at the WHO ICTRP platform and Clinical Research Information Service, KCT0003363. Registered 21 Sep 2018.

Keywords: Collagen sponge; Complication; Periodontal defect; Radiographic; Surgical extraction; Third molar.

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Conflict of interest statement

The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article.

Figures

Fig. 1
Fig. 1
Pre-operative panoramic radiograph showing impacted bilateral mandibular third molars with same Pell-Gregory and Winter classification
Fig. 2
Fig. 2
A comparison of the VAS scores for the sides that received a sponge and those that didn’t. The results are shown as the mean (SE). * indicates P < 0.05 between collagen sponge insertion versus control. Abbreviations; T1, 1 week post-operatively; T2, 2 weeks post-operatively; T3, 14 weeks post-operatively.
Fig. 3
Fig. 3
A comparison of the probing depths for the sides that received a sponge and those that didn’t. The results are shown as the mean (SD). * indicates P < 0.05 between collagen sponge insertion versus control. Abbreviations; T0, Pre-operation; T2, 2 weeks post-operatively; T3, 14 weeks post-operatively
See this image and copyright information in PMC

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