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. 2020 Mar 6:12:151-158.
doi: 10.2147/IJWH.S236443. eCollection 2020.

Obstetric Outcomes of Pregnancy After Uterine Artery Embolization

Mariko Jitsumori #  1 , Shinya Matsuzaki #  1 , Masayuki Endo  1 , Takeya Hara  1 , Takuji Tomimatsu  1 , Satoko Matsuzaki  2 , Tatsuya Miyake  1 , Tsuyoshi Takiuchi  1 , Aiko Kakigano  1 , Kazuya Mimura  1 , Eiji Kobayashi  1 , Yutaka Ueda  1 , Tadashi Kimura  1
Affiliations

Obstetric Outcomes of Pregnancy After Uterine Artery Embolization

Mariko Jitsumori et al. Int J Womens Health. .

Abstract

Background: Uterine artery embolization (UAE) is used to treat severe postpartum hemorrhage (PPH). According to a few studies, UAE for PPH was associated with preterm birth, fetal growth restriction (FGR), and placenta accreta spectrum (PAS) in subsequent pregnancies. These previous studies, however, lacked controls, and to the best of our knowledge, no systematic literature reviews have been conducted thus far. We report the results of our retrospective case-control study of pregnancies after UAE at a single center and include a literature review to evaluate the risk of PAS in pregnancies after UAE.

Methods: We retrospectively reviewed data from deliveries at our hospital between January 2012 and October 2017. We divided the delivery data into cases with previous UAEs performed for PPH (the post-UAE group) and those without UAEs (the non-UAE group, which included women without previous PPH). We defined PAS as cases in which hysterectomy was performed and pathological examination confirmed the diagnosis. Results are presented as odds ratios (ORs) with 95% confidence intervals (95% CIs).

Results: We used data from 3155 patients in this study, of whom 16 patients had undergone UAE (post-UAE group) and 3139 had not (non-UAE group). We found no differences between the groups in terms of frequency of preterm births (12.5% versus 14.2%, respectively; OR, 0.863; 95% CI, 0.218 to 3.414; P = 0.84) or FGR (6.2% versus 10.0%, respectively; OR, 0.602; 95% CI, 0.104 to 3.584; P = 0.61). However, cases of PAS were significantly more common in the post-UAE group (37.5%) than in the non-UAE group (1.2%; OR, 50.303; 95% CI, 17.38 to 145.592; P < 0.01).

Conclusion: Our results suggest that previous UAE is a significant risk factor for PAS.

Keywords: obstetric outcomes; placenta accreta; placenta accreta spectrum; postpartum hemorrhage; uterine artery embolization.

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Conflict of interest statement

Tadashi Kimura reports personal fees from Nihon Kayasu Co. Ltd, outside the submitted work. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Forest plot of odds ratio of placenta accreta spectrum in post-UAE cases. Forest plots show the OR and 95% CI of the risk for PAS. Various combinations were determined, and we revealed that post-UAE is a significant risk factor for PAS except for the P-UAE with PP and p-CD groups. (-) indicates that the patients with pointed factor were excluded. Bold indicates statistical significance. Abbreviations: CD, cesarean delivery, CI, confidence interval; IVF, in vitro fertilization-embryo transfer pregnancy; PAS, placenta accreta spectrum, p-CD; previous cesarean delivery; PP, placenta previa; p-UAE, post-UAE; UAE, uterine artery embolization.
See this image and copyright information in PMC

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